Go ask your competent? doctor which book is better for producing these oscillations. If your doctor doesn't know of both of these, your doctor is fucking incompetent! I take no prisoners in trying to get stroke solved, a lot of dead wood needs to be removed, probably your doctor!
Send me hate mail on this: oc1dean@gmail.com. I'll print your complete statement with your name and my response in my blog. Or are you afraid to engage with my stroke-addled mind? No excuses are allowed, leaders solve problems, you must not be a leader if you're preparing excuses for not getting patients 100% recovered! And what is your definition of competence in stroke? Swearing at me is allowed, I'll return the favor.
'Breath: The New Science of a Lost Art' by James Nestor.
Or;
'' by Patrick McKeown.
Breathing orchestrates synchronization of sleep oscillations in the human hippocampus
Edited by Emery Brown, Massachusetts General Hospital, Boston, MA; received March 18, 2024; accepted November 7, 2024
Significance
Here,
we suggest a hypothesis in which breathing underlies intrinsic
coordination of sleep oscillations in humans. Brain rhythms during sleep
coordinate activity across different neural systems, as part of memory
consolidation processes. These coordinated sleep oscillations occur
throughout non-REM sleep in bursts, and have widely been assumed to
emerge intrinsically during sleep with no underlying rhythm or external
impetus. Recently, however, sleep oscillations have been shown to
coordinate on a slow timescale of about 3 to 6 s. Intriguingly, human
breathing rates overlap with this range. Our findings show that human
breathing drives a slow hippocampal rhythm during sleep, sleep
oscillations in the hippocampus couple to breathing, and respiratory
coupling promotes coordination of sleep oscillations, suggesting a role
in memory consolidation.
Abstract
Nested
sleep oscillations, emerging from asynchronous states in coordinated
bursts, are critical for memory consolidation. Whether these bursts
emerge intrinsically or from an underlying rhythm is unknown. Here, we
show a previously undescribed respiratory-driven oscillation in the
human hippocampus that couples with cardinal sleep oscillations.
Further, breathing promotes nesting of ripples in slow oscillations,
together suggesting that respiration acts as an intrinsic rhythm to
coordinate synchronization of sleep oscillations, providing a unique
framework to characterize sleep-related respiratory and memory
processes.
Data, Materials, and Software Availability
All iEEG, respiratory, and human neuroimaging data have been deposited in Zenodo (100).
Acknowledgments
We
are extremely grateful to the patients who volunteered to participate
in this research. Without their generous contributions of time and
effort, this study would not have been possible. We thank Navid Shadlou
for his technical expertise and assistance with data collection. This
work was funded by the National Institute on Deafness and other
Communication Disorders of the NIH under award numbers R01DC016364,
R01DC018539, and R01DC021663 to C.Z., and by NIH Ruth L. Kirchstein
Institutional National Research Award T32 NS047987 to A.S. The content
is solely the responsibility of the authors and does not necessarily
represent the official views of the NIH.
Author contributions
A.S.,
J.B.M., C.C., G.L., and C.Z. designed research; A.S., J.B.M., C.C.,
K.K.H., J.M.R., S.U.S., and C.Z. performed research; K.K.H., M.O.,
J.M.R., and S.U.S. contributed new reagents/analytic tools; A.S., G.Z.,
and V.S. analyzed data; and A.S., G.L., and C.Z. wrote the paper.
Competing interests
The authors declare no competing interest.
Supporting Information
Appendix 01 (PDF)
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