http://nnr.sagepub.com/content/30/7/661?etoc
A Randomized Controlled Trial on Fast Locomotor Training Combined With Functional Electrical Stimulation
- Louis N. Awad, PhD1⇑
- Darcy S. Reisman, PhD2
- Ryan T. Pohlig, PhD3
- Stuart A. Binder-Macleod, PhD2,3
- 1Harvard University, Cambridge, MA, USA
- 2University of Delaware, Department of Physical Therapy, Newark, DE, USA
- 3Delaware Clinical and Translational Research ACCEL Program, Newark, DE, USA
- Louis N. Awad, Harvard John A. Paulson School of Engineering and Applied Sciences and Wyss Institute for Biologically Inspired Engineering, Harvard University, 60 Oxford Street, Cambridge, MA, USA. Email: louawad@seas.harvard.edu
Abstract
Background. Neurorehabilitation
efforts have been limited in their ability to restore walking function
after stroke. Recent work has
demonstrated proof-of-concept for a functional
electrical stimulation (FES)–based combination therapy designed to
improve
poststroke walking by targeting deficits in paretic
propulsion.
Objectives. To determine the effects on the energy cost of walking (EC) and long-distance walking ability of locomotor training that
combines fast walking with FES to the paretic ankle musculature (FastFES).
Methods.
Fifty participants >6 months poststroke were randomized to 12 weeks
of gait training at self-selected speeds (SS), fast
speeds (Fast), or FastFES. Participants’ 6-minute
walk test (6MWT) distance and EC at comfortable (EC-CWS) and fast
(EC-Fast)
walking speeds were measured pretraining,
posttraining, and at a 3-month follow-up. A reduction in EC-CWS,
independent of
changes in speed, was the primary outcome. Group
differences in the number of 6MWT responders and moderation by baseline
speed
were also evaluated.
Results. When compared with SS and Fast, FastFES produced larger reductions in EC (Ps ≤.03). FastFES produced reductions of 24% and 19% in EC-CWS and EC-Fast (Ps <.001), respectively, whereas neither Fast nor SS influenced EC. Between-group 6MWT differences were not observed; however,
73% of FastFES and 68% of Fast participants were responders, in contrast to 35% of SS participants.
Conclusions.
Combining fast locomotor training with FES is an effective approach to
reducing the high EC of persons poststroke. Surprisingly,
differences in 6MWT gains were not observed between
groups. Closer inspection of the 6MWT and EC relationship and
elucidation
of how reduced EC may influence walking-related
disability is warranted.
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