Abstract
The
chemokine CXCL12 plays a vital role in regulating the development of
the central nervous system (CNS) by binding to its receptors CXCR4 and
CXCR7. Recent studies reported that the CXCL12/CXCR4/CXCR7 axis
regulates both embryonic and adult oligodendrocyte precursor cells
(OPCs) in their proliferation, migration, and differentiation. The
changes in the expression and distribution of CXCL12 and its receptors
are tightly associated with the pathological process of demyelination in
multiple sclerosis (MS), suggesting that modulating the
CXCL12/CXCR4/CXCR7 axis may benefit myelin repair by enhancing OPC
recruitment and differentiation. This review aims to integrate the
current findings of the CXCL12/CXCR4/CXCR7 signaling pathway in the CNS
and to highlight its role in oligodendrocyte development and
demyelinating diseases. Furthermore, this review provides potential
therapeutic strategies for myelin repair by analyzing the relevance
between the pathological changes and the regulatory roles of
CXCL12/CXCR4/CXCR7 during MS.
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