http://europepmc.org/abstract/med/29237377
(PMID:29237377)
Current Pharmaceutical Design
[12 Dec 2017]
Abstract
The aging of western societies is leading to a dramatic increase in the
prevalence of chronic conditions, threatening the health status and then
the sustainability of our healthcare systems. In particular, dementia
is being increasingly recognized as a public health priority, given its
enormous socioeconomic burdens further amplified by the absence of
treatments really effective in improving the clinical course of the
disease.The question of whether some degree of cognitive deterioration
is an inevitable part of aging or should be considered as a pathological
pre-stage of dementia is currently debated. This is a field in need of
research because accelerated brain aging as well as further decline in
cognition might be preventable in the early stages of cognitive
impairment. Herein, we discuss evidence from clinical and experimental
studies on the role of polyphenols in preserving cognitive performance
across life.In recent years, the possibility of favorably influencing
the cognitive trajectory through promotion of lifestyle modifications
has been increasingly investigated. In particular, the relationship
between nutritional habits and brain health has attracted special
attention. Dietary polyphenols exhibit a strong potential to promote
brain due to their efficacy in protecting neurons against oxidative
stress-induced injury, suppressing neuroinflammation and in ameliorating
cardiovascular risk factor control and cardiovascular function thus
counteracting neurotoxicity and neurodegeneration.Emerging evidence
suggest that dietary polyphenols, in particular flavonoids, may exert
beneficial effects on the central nervous system thus representing a
potential tool to preserve cognitive performance throught senescence.
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