Deans' stroke musings: Dopaminergic Pathways in Neuroplasticity After Stroke and Vagus Nerve Stimulation.

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, April 11, 2025

Dopaminergic Pathways in Neuroplasticity After Stroke and Vagus Nerve Stimulation.

Still haven't created vagus nerve protocols!

Steven Cramer should know what needs to be done since he is one of strokes' rock stars.

Dr. Steven Cramer (23 posts to October 2011)

Dopaminergic Pathways in Neuroplasticity After Stroke and Vagus Nerve Stimulation.

Min-Keun Song, Steven C Cramer

Stroke. 2025 Apr 10 [Epub ahead of print]

Stroke remains a significant cause of disability worldwide. In addition to multidisciplinary rehabilitation approaches, various forms of technology, including vagus nerve stimulation, have emerged to facilitate neuroplasticity and, thereby, improve functional status after stroke. Vagus nerve stimulation was recently approved by the Food and Drug Administration, but questions remain regarding its mechanism of action. Here, a potential role for dopaminergic signaling is considered. This review first examines evidence that dopamine is important to neuroplasticity after stroke. Next, 2 different dopaminergic pathways are considered potential mechanisms underlying vagus nerve stimulation-related benefits after stroke, direct modulation of brain dopaminergic pathways, and engagement of systemic dopaminergic pathways such as those found in the gut-brain axis. A contribution of dopamine signaling to vagus nerve stimulation efficacy could have therapeutic implications that extend to a precision medicine approach to stroke rehabilitation.

Source: Stroke