Deans' stroke musings: Metabolites Related to Diet Correlate With Cognitive Function in Older Adults

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Wednesday, November 23, 2022

Metabolites Related to Diet Correlate With Cognitive Function in Older Adults

Is this going to be enough to get your doctor to have the dietician create a diet protocol? It should cover all these needs:

For stroke prevention; for dementia prevention; for cognitive improvement; for cholesterol reduction; for plaque removal; for Parkinsons prevention; for inflammation reduction; for blood pressure reduction.

Metabolites Related to Diet Correlate With Cognitive Function in Older Adults

Serum metabolites suggestive of healthy diets correlate with higher global cognitive functioning, while serum metabolites indicating higher sugar intake correspond to lower global cognitive functioning scores in older adults. These are the findings of a study published in the journal Alzheimer’s & Dementia.

Researchers conducted a cross-sectional observational study based on data obtained from population-based, longitudinal, multisite cohorts of varying racial/ethnic backgrounds, including Hispanic/Latinx (n=2222) from the Community Health Study/Study of Latinos (HCHS/SOL) and those of African (n=478) or European (n=1365) descent in the Atherosclerosis Risk in Communities (ARIC) Study.

In the HCHS/SOL cohort, researchers assessed cognitive function in individuals aged 45 years or older, using 4 tests: the 6-item screener (SIS) for mental status, word fluency for verbal functioning, Brief-Spanish English Verbal Learning Test (B-SVELT) for learning and memory, and digit symbol substitution test for processing speed and executive function. Additional assessments included serum metabolites after fasting and APOE genotyping using whole genome sequencing.

The researchers identified 6 metabolites (5′-Methylthioadenosine, glucose, mannose, ribitol, gamma-CEHC glucuronide, mannitol/sorbitol) that correlated with lower global cognitive functioning across all races and ethnicities, 4 of which related to sugar intake.

Overall, we demonstrated high validity and generalizability of several metabolite associations with global cognitive function across diverse race/ethnicities, specifically metabolites related to sugars.

They analyzed the effect of diet on cognitive function, particularly the Mediterranean diet. They found weak evidence of the causal effects of ribitol (sugar intake) on cognitive function, whereas metabolites, such as beta-cryptoxanthin, reflected a healthy diet rich in fruits and vegetables, which correlated with higher cognitive functioning scores.