You have described a whole series of problems here. 10 million stroke survivors a year want to know how to prevent these problems. When are you going to deliver solutions?
Or are we waiting for SOMEONE ELSE TO SOLVE THE PROBLEM?
Like that will ever occur with the current stroke leadership.
Autoimmunity in acute ischemic stroke and the role of blood-brain barrier: the dark side or the light one?
Abstract
This
article presents a synopsis of the current data on the mechanisms of
blood-brain barrier (BBB) alteration and autoimmune response in acute
ischemic stroke. Most researchers confirm the relationship between the
severity of immunobiochemical changes and clinical outcome of acute
ischemic stroke. Ischemic stroke is accompanied by aseptic inflammation,
which alters the brain tissue and exposes the co-stimulatory molecules
of the immune system and the neuronal antigens. To date, BBB is not
considered the border between the immune system and central nervous
system, and the local immune subsystems are found within and behind the
BBB. BBB disruption contributes to the leakage of brain autoantigens and
induction of secondary autoimmune response to neuronal antigens and
long-term inflammation. Glymphatic system function is altered and
jeopardized both in hemorrhagic and ischemic stroke types. The receptors
of innate immunity (toll-like receptor-2 and toll-like receptor-4) are
also involved in acute ischemia-reperfusion injury. Immune response is
related to the key processes of blood clotting and fibrinolysis. At the
same time, the stroke-induced immune activation may promote reparation
phenomena in the brain. Subsequent research on the reduction of the
acute ischemic brain injury through the target regulation of the immune
response is promising.(And who the fuck is going to do that followup research?)
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