Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, February 25, 2024

Coffee Component Boosts Memory

If you have competent doctors and hospital they will contact stroke leadership to get human testing going.  

Do you prefer your  doctor and hospital incompetence NOT KNOWING? OR NOT DOING?

Coffee Component Boosts Memory

Summary: Trigonelline (TG), a compound in coffee and certain vegetables, is believed to improve cognitive decline in aging. Researchers administered TG to aging mice, noting enhancements in spatial learning and memory.

Deep dives into the hippocampus found that TG bolstered neurotransmitters and curtailed inflammation. This natural compound holds potential in mitigating age-linked cognitive challenges.

Key Facts:

  1. Trigonelline (TG), found in coffee, fenugreek seed, and radish, significantly enhanced spatial learning and memory in aged mice.
  2. TG was discovered to support pathways tied to nervous system development, mitochondrial function, and neurotransmitter release.
  3. The compound also suppressed neuroinflammation and increased key neurotransmitter levels in the hippocampus.

Source: University of Tsukuba

The search for functional natural compounds that can improve age-related cognitive decline has recently emerged as an important research focus to promote healthy aging.

Trigonelline (TG), a plant alkaloid found in coffee, as well as in fenugreek seed and radish, was anticipated to possess cognitive enhancement properties.

This shows a cup of coffee.
These findings suggest the efficacy of TG in preventing and improving age-related spatial learning memory impairment. Credit: Neuroscience News

In this study, researchers led by the University of Tsukuba investigated the effects of TG on memory and spatial learning (acquiring, retaining, structuring, and applying information related to the surrounding physical environment) from both a cognitive and molecular biology perspective in an integrated manner using a senescence-accelerated mouse prone 8 (SAMP8) model.

Following oral administration of TG to SAMP8 mice for 30 days, the Morris water maze test indicated a significant improvement in spatial learning and memory performance compared with SAMP8 mice that did not receive TG.

Next, the researchers performed whole-genome transcriptomic analysis of the hippocampus to explore the underlying molecular mechanisms. They found that signaling pathways related to nervous system development, mitochondrial function, ATP synthesis, inflammation, autophagy, and neurotransmitter release were significantly modulated in the TG group.

Furthermore, the research team found that TG suppressed neuroinflammation by negatively regulating signaling factor Traf6-mediated activation of the transcription factor NF-κB. Additionally, quantitative protein analysis confirmed that the levels of inflammatory cytokines TNF-α and IL-6 were significantly decreased and the levels of neurotransmitters dopamine, noradrenaline, and serotonin were significantly increased in the hippocampus.

These findings suggest the efficacy of TG in preventing and improving age-related spatial learning memory impairment.

Funding: This work was supported by DyDo DRINCO and Japan Science and Technology Agency (JST grant number JPMJPF2017).

About this memory research news

Author: YAMASHINA Naoko
Source: University of Tsukuba
Contact: YAMASHINA Naoko – University of Tsukuba
Image: The image is credited to Neuroscience News

Original Research: Open access.
Transcriptomics and Biochemical Evidence of Trigonelline Ameliorating Learning and Memory Decline in the Senescence-Accelerated Mouse Prone 8 (SAMP8) Model by Suppressing Proinflammatory Cytokines and Elevating Neurotransmitter Release” by KAGAWA, Tamami et al. GeroScience



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