Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, February 22, 2024

Repetitive High Concentration Capsaicin Patch Applications Effective for Nerve Pain in a Real-World Setting

Would this work on CPSP(Central post-stroke pain)?

Central post-stroke pain (CPSP) is a neuropathic pain syndrome that can occur after a cerebrovascular accident. 

If your doctor does nothing, no initiation of research, you don't have a functioning stroke doctor! Over a decade of incompetence! WOW!

  • CPSP (22 posts to December 2011)

 

Repetitive High Concentration Capsaicin Patch Applications Effective for Nerve Pain in a Real-World Setting

Real-world use of a high concentration capsaicin patch (HCCP) reduced pain intensity and concomitant opioid use in patients with neuropathic pain, according to a study published in Pain Practice.

“Consistent with the progressive response seen in prospective clinical trials involving repeated use of topical capsaicin, our research indicates that patients

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appear to benefit from multiple applications in terms of pain intensity and concomitant opioid use in real-world clinical practice,” said Kai-Uwe Kern, MD, Institute for Pain Medicine, Wiesbaden, Germany.

The researchers analysed data from 97 patients who received at least 2 HCCP treatments between January 2011 and July 2022 at an outpatient pain centre in Wiesbaden. Patients were receiving treatment due to neuropathic back pain, postoperative or post-traumatic neuropathic pain, or postherpetic neuralgia.

On average, patients were 1.7 years on HCCP treatment, received 5.9 repeated treatments, and 1.2 patches per application. Average time between applications was 3 months. The majority of patients received concomitant medications, with opioids, anticonvulsants, and antidepressants being the most common.

The average morphine equivalent daily dose was 88 mg at the beginning of HCCP treatment and was significantly (P = .0446) reduced by 5 mg when comparing with the average daily dose received within 2 years (83 mg). The average daily dose increased in 13 patients, decreased in 21 patients, and remained constant within the HCCP treatment in 18 patients.

Reduction in the average daily dose of morphine equivalent was higher in patients with at least 3 applications (-6.8 mg) compared with patients who received exactly two applications (-3.1 mg).

“Our results demonstrate that two-thirds of patients treated with at least 2 HCCP applications experienced an improvement in pain intensity,” the authors wrote. “This finding underscores the potential benefits of HCCP as an effective treatment modality for pain relief. Importantly, the proportion of patients experiencing a significant improvement in pain intensity was substantially higher among those who received at least 3 applications compared with those with exactly 2 applications, suggesting an increase in response with multiple HCCP application.”

The authors stated that further research and larger-scale studies are warranted to validate the results of their study and elucidate the optimal treatment protocols for maximising the benefits of HCCP in pain management.

Reference: https://onlinelibrary.wiley.com/doi/10.1111/papr.13345

SOURCE: Wiley

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