Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, February 4, 2024

Motor and Premotor Cortices in Subcortical Stroke: Proton Magnetic Resonance Spectroscopy Measures and Arm Motor Impairment

Useless! Nothing here is going to get survivors recovered! You're all fired!

Motor and Premotor Cortices in Subcortical Stroke: Proton Magnetic Resonance Spectroscopy Measures and Arm Motor Impairment

 Sorin C. Craciunas, MD, PhD ,1,
William M. Brooks, PhD a,c,,
Randolph J. Nudo, PhD,b,d,
Elena A. Popescu, PhD a,
In-Young Choi, PhD a,c,
Phil Lee, PhD a,d,
Hung-Wen Yeh, PhD
e
,
Cary R Savage, PhD
f
, and
Carmen M. Cirstea, MD, PhD
a,c,g,*
a Hoglund Brain Imaging Center, University of Kansas Medical Center
b Landon Center on Aging; Departments of, University of Kansas Medical Center
c Neurology, University of Kansas Medical Center
d Molecular and Integrative Physiology, University of Kansas Medical Center
e Biostatistics, University of Kansas Medical Center
f Psychiatry and Behavioral Sciences, University of Kansas Medical Center
g Physical Therapy and Rehabilitation Science, University of Kansas Medical Center

 Abstract

Background—
Although functional imaging and neurophysiological approaches reveal alterations in motor and premotor areas after stroke, insights into neurobiological events underlying these alterations are limited in human studies.
Objective—
We tested whether cerebral metabolites related to neuronal and glial compartments are altered in the hand representation in bilateral motor and premotor areas and correlated with distal and proximal arm motor impairment in hemiparetic persons.
Methods—
In twenty participants at >6 months post-onset of a subcortical ischemic stroke and sixteen age and sex-matched healthy controls, the concentrations of N-acetylaspartate and myoinositol were quantified by proton magnetic resonance spectroscopy (1H-MRS). Regions of interest, identified by functional MRI, included primary (M1), dorsal premotor (PMd), andsupplementary (SMA) motor areas. Relationships between metabolite concentrations and distal(hand) and proximal (shoulder/elbow) motor impairment using Fugl-Meyer Upper Extremity(FMUE) subscores were explored.
Results—
N-acetylaspartate was lower in M1 (p=0.04) and SMA (p=0.004) and myo-inositol was higher in M1 (p=0.003) and PMd (p=0.03) in the injured (ipsilesional) hemisphere after stroke compared to the left hemisphere in controls. N-acetylaspartate in ipsilesional M1 was positively correlated with hand FMUE subscores (p=0.04). Significant positive correlations were also found between N-acetylaspartate in ipsilesional M1, PMd, and SMA and in contralesional M1 and shoulder/elbow FMUE subscores (p=0.02, 0.01, 0.02 and 0.02 respectively).
*
Corresponding author
 Hoglund Brain Imaging Center University of Kansas Medical Center 3901 Rainbow Blvd Mail Stop 1052Kansas City, Kansas US, 66160 Tel: (913) 588-4373 Fax: (913) 588-9071 .1
Present address
: Neurosurgery Department IV, Bagdasar-Arseni Hospital
NIH Public Access
Author Manuscript
 Neurorehabil Neural Repair
. Author manuscript; available in PMC 2014 June 01.
Published in final edited form as:
 Neurorehabil Neural Repair
. 2013 June ; 27(5): 411–420. doi:10.1177/1545968312469835.

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