Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, March 23, 2024

Quercetin attenuated ischemic stroke induced neurodegeneration by modulating glutamatergic and synaptic signaling pathways

Didn't your competent? doctor start using this 6 years ago? Oh, you don't have a competent doctor , do you? Will your doctor ensure that further research gets done in humans?

 Quercetin attenuated ischemic stroke induced neurodegeneration by modulating
glutamatergic and synaptic signaling pathways

Journal Pre-proof

Heliyon 9 (2023) e15532
Quercetin Attenuated Ischemic Stroke Induced Neurodegeneration
by Modulating Glutamatergic and Synaptic Signaling Pathways
Fawad Ali Shah1, Faisal Albaqami1, Abdullah Alattar 2, Reem Alshaman 2, Sawsan A. Zaitone3,4, Attia
M. Gabr5,6, Abdel-Moneim Hafez Abdel-Moneim7,8, Mohamed El-dosoky 9, Phil Ok Koh10
(1) Department of Pharmacology and Toxicology, College of Pharmacy, Prince Sattam Bin Abdulaziz University, Al-Kharj
11942, Saudi Arabia.
(2) Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia
(3) Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Tabuk, Tabuk, Saudi Arabia.
(4) Department of Pharmacology and Toxicology, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt.
(5) Pharmacology and Therapeutics Department, College of Medicine, Qassim University, Qassim, Saudi Arabia
(6) Department of Clinical Pharmacology, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt.
(7) Department of Physiology, College of Medicine, Qassim University, Qassim, Saudi Arabia.
(8) Department of Physiology, Faculty of Medicine, Mansoura University, Egypt
(9) Department of Neuroscience Technology, College of Applied Medical Sciences in Jubail, Imam Abdulrahman Bin Faisal
University, Jubail, Saudi Arabia.
(10) Department of Anatomy and Histology, College of Veterinary Medicine, Research Institute of Life Science, Gyeongsang
National University, 501 Jinjudaero, Jinju 52828, South Korea.
DOI: https://doi.org/10.1016/j.heliyon.2024.e28016
Reference: HLY 28016
To appear in: HELIYON
Received Date: 28 May 2023
Revised Date: 7 March 2024
Accepted Date: 11 March 2024
Please cite this article as: , Quercetin attenuated ischemic stroke induced neurodegeneration
by modulating glutamatergic and synaptic signaling pathways, HELIYON (2024), doi: https://
doi.org/10.1016/j.heliyon.2024.e28016.
This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

ABSTRACT

Ischemic strokes originate whenever the circulation to the brain is interrupted, either temporarily or permanently, resulting in a lack of oxygen and other nutrients. This deprivation primarily impacts the cerebral cortex and striatum, resulting in neurodegeneration(Actually neuronal death). Several experimental stroke models have demonstrated that the potent antioxidant quercetin offers protection against stroke-related damage.
Multiple pathways have been associated with quercetin's ability to safeguard the brain from ischemic injury. This study examines whether the administration of quercetin alters glutamate NMDA and GluR1 receptor signaling in the cortex and striatum 72 hours after transient middle cerebral artery occlusion.
The administration of 10 mg/kg of quercetin shielded cortical and striatal neurons from cell death
induced by ischemia in adult SD rats. Quercetin reversed the ischemia-induced reduction of
NR2a/PSD95, consequently promoting the pro-survival AKT pathway and reducing CRMP2
phosphorylation. Additionally, quercetin decreased the levels of reactive oxygen species and
inflammatory pathways while increasing the expression of the postsynaptic protein PSD95. Our results suggest that quercetin may be a promising neuroprotective drug for ischemic stroke therapy as it recovers neuronal damage via multiple pathways.
Content
© 2024 Published by Elsevier Ltd.

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