Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, October 24, 2021

Multidimensional phase I dose ranging trials for stroke recovery interventions: Key challenges and how to address them

This is so fucking simple to explain why stroke rehab doesn't work. 

1. You have too many dead neurons; The neuronal cascade of death  is causing billions of neurons to die the first week.

2. You don't know how to make neuroplasticity exactly repeatable.

3. You don't have the correct goal of 100% recovery, as a result your researchers are going for little incremental wins, not BHAGs(Big Hairy Audacious Goals.


Multidimensional phase I dose ranging trials for stroke recovery interventions: Key challenges and how to address them

Neurorehabilitation and Neural Repair , Volume 35(8) , Pgs. 663-679.

NARIC Accession Number: J87242.  What's this?
ISSN: 1044-2073.
Author(s): Dalton, Emily J. ; Churilov, Leonid ; Lannin, Natasha A. ; Corbett, Dale ; Campbell, Bruce C. V. ; Hayward, Kathryn S..
Publication Year: 2021.
Number of Pages: 17.
Abstract: Article describes the problem of insufficient use of a systematic approach to early-phase, multidimensional dose articulation research and proposes a solution that applies this approach to design a multidimensional phase I trial to identify the maximum tolerated dose. Despite an increase in the amount of published stroke recovery research, interventions have failed to markedly affect the trajectory of recovery poststroke. The authors argue that early-phase research to systematically investigate dose is an important contributor to advance the science underpinning stroke recovery. They present a design template as a decision-support tool to increase knowledge of how to develop a phase I dose-ranging trial for nonpharmaceutical stroke recovery interventions. This solution has the potential to advance the development of efficacious stroke recovery interventions, which include activity-based rehabilitation interventions.
Descriptor Terms: HEALTH PROMOTION, INTERVENTION, REHABILITATION SERVICES, RESEARCH METHODOLOGY, SERVICE DELIVERY, STROKE.


Can this document be ordered through NARIC's document delivery service*?: Y.

Citation: Dalton, Emily J. , Churilov, Leonid , Lannin, Natasha A. , Corbett, Dale , Campbell, Bruce C. V. , Hayward, Kathryn S.. (2021). Multidimensional phase I dose ranging trials for stroke recovery interventions: Key challenges and how to address them.  Neurorehabilitation and Neural Repair , 35(8), Pgs. 663-679. Retrieved 10/23/2021, from REHABDATA database.

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