Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, April 14, 2025

Aerobic Exercise Restores Hippocampal Neurogenesis and Cognitive Function by Decreasing Microglia Inflammasome Formation Through Irisin/NLRP3 Pathway

You'll want your competent? doctor to get you recovered enough to do these exercises to reduce this part of your Parkinson's risk.  

 Did your incompetent doctors and hospital do anything about getting NLRP3 inflammasone research done after this earlier research came out in February 2020? NO? Then you don't have a functioning stroke doctor or hospital.  I expect a competent doctor to know more than I do!

Molecular 'switch' reverses chronic inflammation and aging

 February 2020 

And this; March 2023

Berberine ameliorates depression-like behaviors in mice via inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing neuroplasticity disruption

The latest here:

 Aerobic Exercise Restores Hippocampal Neurogenesis and Cognitive Function by Decreasing Microglia Inflammasome Formation Through Irisin/NLRP3 Pathway

1 of 17Aging Cell, 2025; 0:e70061
https://doi.org/10.1111/acel.70061
Aging Cell
RESEARCH ARTICLE OPEN ACCESS
Aerobic Exercise Restores Hippocampal
Neurogenesis and Cognitive Function by Decreasing
Microglia Inflammasome Formation Through
Irisin/NLRP3 Pathway
Renqing Zhao | Xin Tian | Haocheng Xu | Yuanxin Wang | Junjie Lin | Bin Wang
College of Physical Education, Yangzhou University, Yangzhou, China
Correspondence: Renqing Zhao (zhrenqing@gmail.com)
Received: 29 November 2024 | Revised: 26 February 2025 | Accepted: 14 March 2025
Funding: This work was supported by the Natural Science Foundation of Jiangsu Province (BK20201435).
Keywords: aerobic exercise | cognition | FNDC5/irisin | hippocampal neurogenesis | NLRP3 inflammasome | Parkinson disease

ABSTRACT

Persistent microglial inflammation is a detrimental contributor to the progression of Parkinson disease (PD) pathology and related issues such as impaired adult hippocampal neurogenesis (AHN) and cognition. We conducted a 10-week exercise program with MPTP-treated mice to determine whether neuroinflammation can be addressed by aerobic exercise and elucidate its underlying regulatory mechanisms. Ten weeks of exercise significantly reduced PD-related pathology and enhanced AHN and
memory. These changes were linked to a reduction in neuronal apoptosis, microglial inflammation, and NLRP3 inflammasome activation. In cultured microglia, fibril α-synuclein reduced FNDC5/irisin protein levels and induced NLRP3 inflammasome formation and IL-1β production, which could be diminished by recombinant irisin treatment. Interestingly, “runner serum” isolated from exercising rodents enhanced FNDC5/irisin expression and reduced NLRP3 inflammasome components and IL-1β
secretion in α-synuclein-treated microglia. These effects could be diminished by blocking irisin signaling with cyclo RGDyk or NLRP3 agonist, nigericin sodium salt. Exercise-induced neuroprotective effects were weakened by treatment of MPTP-treated mice with cyclo RGDyk. In contrast, systematic administration of irisin partially replicated the beneficial effects of exercise
on PD pathology, AHN, and memory function. As a nonpharmacological strategy, aerobic exercise effectively addresses PD pathology and preserves adult neurogenesis and cognition by mitigating microglial inflammation via mediating irisin/NLRP3 inflammasome pathways.
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