http://m.medicalxpress.com/news/2016-11-early-intervention-brain-inflammatory-pathways.html
This month in the JCI, work from Laura Sansing's lab at Yale School of Medicine examined the pathways in the brain that drive injury-producing inflammation. They identified a signaling protein that plays a pivotal role in activating immune system-mediated damage after intracerebral hemorrhage. In a mouse model, they observed that intracerebral hemorrhage-driven inflammation began to clear up at the same time as the TGF-β1 pathway was activated in local immune cells.
Treating mice with TGF-β1 immediately after the initial injury reduced pro-inflammatory signals and improved motor function compared to untreated mice. In a patient population, they also observed that higher bloodstream levels of TGF-β1 in the first 3 days following intracerebral hemorrhage predicted better outcomes 3 months into recovery.
Together, these results suggest that targeting the TGF-β1 pathway may have protective effects in individuals recovering from stroke and brain injury.
More information: Roslyn A. Taylor et al, TGF-β1 modulates microglial phenotype and promotes recovery after intracerebral hemorrhage, Journal of Clinical Investigation (2016). DOI: 10.1172/JCI88647
Provided by: JCI Journals
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