Deans' stroke musings: UVB Exposure Prevents Atherosclerosis by Regulating Immunoinflammatory Responses

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, December 22, 2016

UVB Exposure Prevents Atherosclerosis by Regulating Immunoinflammatory Responses

Ask your doctor to translate how much UVB radiation the mice were getting and how much comes from sunlight and map that to your body size. Will you need to join a nudist group and attend every weekend?
http://atvb.ahajournals.org/content/37/1/66?etoc=

, Tomoya Yamashita, , , Tomoyuki Yamaguchi, Takuo Emoto, Keiko Yodoi, , Kenji Nakajima, , , , Tomohiro Hayashi, Yoshihiro Sasaki, , , Ken Washio, , , Chikako Nishigori, Ken-ichi Hirata

https://doi.org/10.1161/ATVBAHA.116.308063

Arteriosclerosis, Thrombosis, and Vascular Biology. 2017;37:66-74

Originally published October 20, 2016

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Visual Overview

Abstract

Objective—UVB irradiation is an established treatment for immunoinflammatory cutaneous disorders and has been shown to suppress cutaneous and systemic inflammatory diseases through modulation of the adaptive immune response. However, it remains unknown whether UVB irradiation prevents an immunoinflammatory disease of arteries such as atherosclerosis.

Approach and Results—Here, we show that UVB exposure inhibits the development and progression of atherosclerosis in atherosclerosis-prone mice by expanding and enhancing the functional capacity of CD4⁺ forkhead box P3⁺ regulatory T cells and regulating proatherogenic T-cell responses. Experimental studies in Langerhans cell–depleted mice revealed that epidermal Langerhans cells play a critical role in UVB-dependent induction of CD4⁺ forkhead box P3⁺ regulatory T cells, suppression of proatherogenic T-cell responses, and prevention of atherosclerotic plaque development.

Conclusions—Our findings suggest the skin immune system as a novel therapeutic target for atherosclerosis and provide a novel strategy for the treatment and prevention of atherosclerosis.