Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, December 23, 2016

Enhanced photocytotoxicity of curcumin delivered by solid lipid nanoparticles

Curcumin is good for us. Hopefully your doctor is prescribing some. This might be a way to get it directly into the brain.
Curcumin for these reasons; I'm sure your doctor has told you all about them.

Investigation of the effects of solid lipid curcumin on cognition and mood in a healthy older population

Curcumin boosts DHA in the brain: Implications for the prevention of anxiety disorders

Curcumin, Compound In Turmeric, Found To Impair Fear Memories And Ease PTSD Symptoms

1.  Dietary Strategy to Repair Plasma Membrane After Brain Trauma Implications for Plasticity and Cognition

2.  Curcumin: Mechanism, Medicinal Uses and Health Benefits

3.  Curcumin Loaded Nanoparticles Potently Induce Adult Neurogenesis and Reverse Cognitive Deficits in Alzheimer’s Disease Model via Canonical Wnt/β-catenin Pathway

4.  Dietary Strategy to Repair Plasma Membrane After Brain Trauma Implications for Plasticity and Cognition

5.  Neuroprotection by Curcumin in Ischemic Brain Injury Involves the Akt/Nrf2 Pathway

6.  Silica-coated flexible liposomes as a nanohybrid delivery system for enhanced oral bioavailability of curcumin

7.  tumeric and stroke rehab

8.  Enhancing absorption and bioavailability of curcumin and turmeric


The latest here:

Enhanced photocytotoxicity of curcumin delivered by solid lipid nanoparticles

          
Authors Jiang S, Zhu R, He X, Wang J, Wang M, Qian Y, Wang S
Received 24 September 2016
Accepted for publication 10 November 2016
Published 22 December 2016 Volume 2017:12 Pages 167—178
DOI https://doi.org/10.2147/IJN.S123107
Checked for plagiarism Yes
Review by Single-blind
Peer reviewers approved by Dr Jia Fan
Peer reviewer comments 2
Editor who approved publication: Dr Linlin Sun
Shan Jiang,1 Rongrong Zhu,1 Xiaolie He,1 Jiao Wang,1 Mei Wang,1 Yechang Qian,2 Shilong Wang1

1Tenth People’s Hospital, School of Life Science and Technology, Tongji University, 2Department of Respiratory Disease, Baoshan District Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai, People’s Republic of China

Abstract: Curcumin (Cur) is a promising photosensitizer that could be used in photodynamic therapy. However, its poor solubility and hydrolytic instability limit its clinical use. The aim of the present study was to encapsulate Cur into solid lipid nanoparticles (SLNs) in order to improve its therapeutic activity. The Cur-loaded SLNs (Cur-SLNs) were prepared using an emulsification and low-temperature solidification method. The functions of Cur and Cur-SLNs were studied on the non-small cell lung cancer A549 cells for photodynamic therapy. The results revealed that Cur-SLNs induced ~2.27-fold toxicity higher than free Cur at a low concentration of 15 µM under light excitation, stocking more cell cycle at G2/M phase. Cur-SLNs could act as an efficient drug delivery system to increase the intracellular concentration of Cur and its accumulation in mitochondria; meanwhile, the hydrolytic stability of free Cur could be improved. Furthermore, Cur-SLNs exposed to 430 nm light could produce more reactive oxygen species to induce the disruption of mitochondrial membrane potential. Western blot analysis revealed that Cur-SLNs increased the expression of caspase-3, caspase-9 proteins and promoted the ratio of Bax/Bcl-2. Overall, the results from these studies demonstrated that the SLNs could enhance the phototoxic effects of Cur.
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