I got nothing out of this. How the hell do you increase intrinsic connectivity? The result of this research is that 10 million yearly stroke survivors will need to set up their own research to figure this out. That is the height of insanity. The stroke medical world seems to have fewer brains than those 10 million yearly stroke survivors.
Increased intrinsic connectivity for structural atrophy and functional maintenance after acute ischemic stroke
First published: 25 January 2019
This article has been accepted for publication and undergone
full peer review but has not been through the copyediting, typesetting,
pagination and proofreading process, which may lead to differences
between this version and the Version of Record. Please cite this article
as doi: 10.1111/ene.13913
Abstract
Background
Significant clinical recovery has been commonly observed in ischemic stroke patients with irreversible brain structural damage. However, brain mechanisms that help to maintain clinical function remain unclear.Methods
Sixty‐two patients with acute ischemic stroke underwent longitudinal clinical assessments and MRI scanning. We evaluated clinical recovery trajectory using Hierarchical Linear Model and analysed intrinsic connectivity with a seed‐based approach to examine its changing pattern based on the regional volume changes calculated using voxel‐wise analysis.Results
We observed that clinical outcome measures improved mainly in the short‐term period (baseline vs. 3 weeks) and then remained stable. Gray matter volume was reduced significantly in bilateral caudate over the entire 3‐year long‐term period. Significant intrinsic connectivity increases in caudate‐middle cingulum over the short‐term period and in caudate‐precuneus and caudate‐calcarine over the long‐term period were observed. Finally, we found that increased caudate‐calcarine connectivity was associated with reduced right caudate volume, and a positive correlation was found between increased caudate‐middle cingulum connectivity and the amount of the modified Rankin score changes.Conclusions
Increased intrinsic connectivity found in this study tends to be a compensatory mechanism for post‐stroke structural damage, associated with clinical recovery. This study helped in understanding the significance(But did nothing to help survivors) of enhanced intrinsic connectivity in post‐stroke long‐term assessment and rehabilitation.This article is protected by copyright. All rights reserved.
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