If we had ANY LEADERSHIP AT ALL in stroke, this research would have been: 'The protocols used to treat Pediatric Large Vessel Occlusion Stroke for 100% recovery'. But no, we get useless crapola like this.
Incidence and Natural History of Pediatric Large Vessel Occlusion Stroke
Question What is the incidence and natural history of arterial ischemic stroke due to large vessel occlusion in the pediatric population?
Findings In this cohort study that included 166 admissions for pediatric arterial ischemic stroke, 39 (23.5%) had a large vessel occlusion. The incidence of pediatric large vessel occlusion stroke was 0.24 per 100 000 children per year, and patients with large vessel occlusion who were treated conservatively had poor neurological outcomes, with 19 (73.1%) experiencing moderate to severe disability or death at 3 months.
Meaning In this study, the natural history of large vessel occlusion stroke in children was poor when treated conservatively, contrary to historic beliefs.
Importance The incidence and natural history of large vessel occlusion (LVO) stroke in children is largely unknown. These knowledge gaps limit the uptake of reperfusion therapies and reduce the efficiency of pediatric acute stroke pathways.
Objective To determine the incidence and natural history of pediatric LVO stroke.
Design, Setting, and Participants This retrospective population-based cohort study was conducted between January 2010 and December 2019, with a mean (SD) follow-up of 37.0 (28.8) months. Admissions from all pediatric hospitals in the state of New South Wales, Australia, with a final diagnosis of arterial ischemic stroke (AIS) in patients 1 month to younger than 17 years were included. A total of 85 of 251 identified cases were excluded based on selection criteria. Data were analyzed from July 2020 to June 2021.
Exposures One-third of patients with LVO received mechanical thrombectomy with or without intravenous thrombolysis while the remainder were treated conservatively.
Main Outcomes and Measures The primary outcome was the pediatric modified Rankin Scale (ped-mRS) score 3 months after stroke. Ordinal logistic regression was used to compare non-LVO, LVO without thrombectomy, and LVO with thrombectomy groups.
Results Of 161 included patients, 56 (34.8%) were female, and the mean (SD) age was 6.1 (5.4) years. A total of 166 AIS admissions were studied, and clinical follow-up was available for 164 of 166 admissions. LVO was present in 39 admissions (23.5%). The incidence of LVO stroke was 0.24 per 100 000 patients per year (95% CI, 0.13-0.35). Patients with LVO who did not receive thrombectomy (n = 26) had poor neurological outcomes, with 19 (73.1%) experiencing moderate to severe disability or death (ped-mRS score of 3 to 6) at 3 months (6 of 12 patients receiving thrombectomy [50.0%]; 25 of 38 patients with LVO [65.8%]). Patients with LVO without thrombectomy had significantly worse clinical outcomes than patients with non-LVO at 3 months (odds ratio, 3.64; 95% CI, 1.68-7.87; P = .001). Most patients with LVO presented within time windows suitable for thrombectomy (27 of 39 [69.2%] within 6 hours; 35 of 39 [89.7%] within 24 hours).
Conclusions and Relevance In this population-based cohort study, the natural history of pediatric patients with LVO stroke treated conservatively was poor, with most experiencing lifelong disability or death. Nearly 90% of pediatric patients with LVO presented within time windows suitable for thrombectomy.
