Deans' stroke musings: Effect of Probiotics on Blood Pressure

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, September 12, 2017

Effect of Probiotics on Blood Pressure

Will your doctor and stroke hospital take this to heart and create a diet blood pressure protocol with this? I bet your doctor and hospital have been completely incompetent in this for years, waiting for SOMEONE ELSE TO SOLVE THE PROBLEM? It is no skin off their butts.
http://hyper.ahajournals.org/content/64/4/897.long

A Systematic Review and Meta-Analysis of Randomized, Controlled Trials

Saman Khalesi, , Nicholas Buys,

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https://doi.org/10.1161/HYPERTENSIONAHA.114.03469

Hypertension. 2014;64:897-903

Originally published July 21, 2014

Abstract

Previous human clinical trials have shown that probiotic consumption may improve blood pressure (BP) control. The aim of the present systematic review was to clarify the effects of probiotics on BP using a meta-analysis of randomized, controlled trials. PubMed, Scopus, Cochrane Library (Central), Physiotherapy Evidence Database, and Clinicaltrial.gov databases were searched until January 2014 to identify eligible articles. Meta-analysis using a random-effects model was chosen to analyze the impact of combined trials. Nine trials were included. Probiotic consumption significantly changed systolic BP by −3.56 mm Hg (95% confidence interval, −6.46 to −0.66) and diastolic BP by −2.38 mm Hg (95% confidence interval, −2.38 to −0.93) compared with control groups. A greater reduction was found with multiple as compared with single species of probiotics, for both systolic and diastolic BP. Subgroup analysis of trials with baseline BP ≥130/85 mm Hg compared with <130/85 mm Hg found a more significant improvement in diastolic BP. Duration of intervention <8 weeks did not result in a significant reduction in systolic or diastolic BP. Furthermore, subgroup analysis of trials with daily dose of probiotics <10¹¹ colony-forming units did not result in a significant meta-analysis effect. The present meta-analysis suggests that consuming probiotics may improve BP by a modest degree, with a potentially greater effect when baseline BP is elevated, multiple species of probiotics are consumed, the duration of intervention is ≥8 weeks, or daily consumption dose is ≥10¹¹ colony-forming units.

Introduction

Blood pressure (BP) has been strongly and positively associated with the risk of chronic diseases, including ischemic heart disease, heart failure, stroke, and kidney disease.^1,2 BP can be controlled through diet and lifestyle modification to prevent hypertension (systolic BP [SBP] ≥140 mm Hg or diastolic BP [DBP] ≥90 mm Hg) or related complications.³ Evidence suggests that low-fat diets rich in fruits and vegetables and low in sodium can lower BP.^4–6 Previous studies have also found that dietary constituents and supplements such as omega-3 fatty acids,⁷ garlic,⁸ and green tea^9,10 can improve BP control.

In recent years, the health benefits of probiotics have attracted increased attention. Probiotics are defined as live microorganisms that may have health benefits for the host if consumed in adequate amounts.¹¹ Probiotics are well studied for their health benefits in improving immune system function¹² and preventing diarrhea.^13,14 It has also been demonstrated that probiotics and their products can improve BP through mechanisms including improving total cholesterol and low-density lipoprotein cholesterol levels,^15–17 reducing blood glucose level and insulin resistance,^18,19 and regulating the renin–angiotensin system.^20,21

A recent systematic review and meta-analysis of 14 randomized, controlled trials showed that consumption of fermented milk containing inhibitory peptides (with or without probiotics) can significantly reduce SBP and DBP.²² However, the effects of probiotics (live bacteria) and their species or dose were not systematically investigated. Some previous studies on probiotics have reported that consumption of probiotic yogurt for 8 weeks can significantly improve BP,^23,24 whereas another study showed no benefit.²⁵ Because of inconclusive reports on the effect of probiotics on BP and lack of information on effective intervention characteristics, the current systematic review and meta-analysis of randomized, controlled trials has been conducted. The findings from this meta-analysis may provide further information on the effective probiotic species, duration or dose of consumption required to confer health, and BP benefits.