Glitazone use associated with reduced risk of Parkinson's disease

Your doctor should have you well versed in prevention of Parkinsons already. But better to be prepared without them. I'm doing everything possible not to get this since my Dad has it. 14 posts on Parkinsons prevention here.

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Glitazone use associated with reduced risk of Parkinson's disease

Movement Disorders

Brakedal B, et al. - The authors embraced this study to investigate if the use of glitazone drugs was correlated with a lower incidence of Parkinson's disease (PD) among diabetic patients. In populations with diabetes, the use of glitazones was associated with a decreased risk of incident PD. To confirm and understand the role of glitazones in neurodegeneration, further studies were warranted.

Methods

• The incidence of PD was compared among individuals with diabetes who used glitazones, with or without metformin, and individuals using only metformin in the Norwegian Prescription Database.
• This database contains all prescription drugs dispensed for the entire Norwegian population.
• During a 10-year period, 94,349 metformin users and 8396 glitazone users were identified.
• The authors compared the incidence of PD in the 2 groups using Cox regression survival analysis, with glitazone exposure as a time-dependent covariate.

Results

• Compared with metformin-only use, glitazone use was correlated with a significantly lower incidence of PD (hazard ratio, 0.72; 95% confidence interval, 0.55-0.94; P = 0.01).