The only problem here is that you have to remove the brain from the mouse. Unlikely to get human clinical participants.
https://www.newscientist.com/article/mg23531454-700-seethrough-brains-reveal-how-stroke-damages-vital-blood-vessels/?
NOW
we can see stroke damage in 3D. A technique that turns mouse brains
transparent has given us the most detailed view yet of how stroke cuts
off the blood supply in the brain.
Stroke damages the brain’s blood vessels, stopping oxygen and
nutrients reaching cells. To understand this impact, researchers usually
examine thin brain slices under the microscope.
Now Dirk Hermann and Matthias Gunzer at the University of
Duisburg-Essen in Germany and their team have developed a way to see all
of a brain’s blood vessels clearly, without having to slice it up. They
injected a fluorescent gel into the hearts of mice, waited for it to be
pumped around the body, and then removed the brains and soaked them in
chemicals. “You’re left with a brain that is clear like glass,” says
Hermann.
The team looked at each brain under a microscope, lighting up the fluorescent gel using a laser (Journal of Cerebral Blood Flow and Metabolism, doi.org/cdg3).
The brains of mice that had experienced a stroke provided the
first-ever 3D view of how stroke cuts off the blood supply to parts of
the brain. “You could see which capillaries had died and how the
surviving ones were reorganising themselves,” says Gunzer.
This article appeared in print under the headline “Transparent brains reveal stroke damage”
Video here:
https://youtu.be/mIrdzam-Xlg
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