Cannabigerol Attenuates Memory Impairments, Neurodegeneration, and Neuroinflammation Caused by Transient Global Cerebral Ischemia in Mice

 If you have ANY COMPETENCY AT ALL in your stroke medical 'professionals' then this will soon be tested in humans. But I see none! NOTHING WILL OCCUR!

Do you prefer your doctor and hospital incompetence NOT KNOWING? OR NOT DOING?

More proof of their extreme incompetence!

Post stroke anxiety(20% chance). 

Cannabigerol (CBG) Reduces Anxiety and Improves Memory August 2024 

The latest here:

Cannabigerol Attenuates Memory Impairments, Neurodegeneration, and Neuroinflammation Caused by Transient Global Cerebral Ischemia in Mice

Nathalia Akemi Neves Kohara,José Guilherme Pinhatti Carrasco,Luís Fernando Fernandes Miranda,Pablo Pompeu Quini,Elaine Del-Bel Guimarães,

Humberto Milani

,

Rúbia Maria Weffort De Oliveira  ^*,

Cristiano Correia Bacarin  ^*

This version is not peer-reviewed.

Abstract

Evidence supporting the clinical use of neuroprotective drugs for cerebral ischemia remains limited. Spatial and temporal disorientation, along with cognitive dysfunction, are among the most prominent long-term consequences of hippocampal neurodegeneration following cerebral ischemia. Cannabigerol (CBG), a non-psychotomimetic constituent of Cannabis sativa, has demonstrated neuroprotective effects in experimental models of cerebral injury. This study investigated the neuroprotective mechanisms of CBG in mitigating memory impairments caused by transient global cerebral ischemia in C57BL/6 mice using the bilateral common carotid artery occlusion (BCCAO) model. Mice underwent sham or BCCAO surgeries and received intraperitoneal (i.p.) injections of either a vehicle or CBG (1, 5, or 10 mg/Kg), starting 1 h post-surgery and continuing daily for 7 days. Spatial memory performance and depression-like behaviors were assessed using the object location test (OLT) and tail suspension test (TST), respectively. Additional analyses examined neuronal degeneration, neuroinflammation, and neuronal plasticity markers in the hippocampus. CBG attenuated ischemia-induced memory deficits, reduced neuronal loss in the hippocampus, and enhanced neuronal plasticity. These findings suggest that CBG’s neuroprotective effects against BCCAO-induced memory impairments may be mediated by reductions in neuroinflammation and modifications in neuroplasticity within the hippocampus.

Keywords: 

Bilateral common carotid artery occlusion

;  

Glial response

;  

Cognition

;  

Neuroprotection

;  

Cannabigerol

Subject: 

Medicine and Pharmacology  -   Neuroscience and Neurology

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