I bet your incompetent doctor still hasn't had the dietician create diet protocols for hospital use and discharge!
For dementia prevention; for cognitive improvement; for cholesterol reduction; for plaque removal; for Parkinsons prevention; for inflammation reduction; etc.
Do you prefer your doctor and hospital incompetence NOT KNOWING? OR NOT DOING?
Let's see how long your doctor has been incompetent:
Dementia Linked to Inflammatory Foods November 2021
diet protocol (83 posts to January 2018)
The latest here:
Better Diet, Better Brains
Midlife diet improvement tied to better white matter integrity at age 70
Key Takeaways
- Better midlife diet was tied to better brain connectivity and white matter integrity later in life.
- Lower waist-to-hip ratio was associated with better memory and executive function at 70.
- Diet improvements over time were linked with better white matter integrity in several brain regions.
Healthier diet and lower waist-to-hip ratio throughout midlife were associated with better brain and cognitive health in older age, longitudinal data from the Whitehall II cohort study in England showed.
A better midlife diet was associated with higher functional connectivity between the left hippocampus and occipital lobe and cerebellum later in life and better white matter integrity (P<0.05 for both), reported Daria Jensen, DPhil, of the Max Planck Institute for Human Cognitive and Brain Sciences in Leipzig, Germany, and co-authors.
A lower midlife waist-to-hip ratio was tied to better working memory and executive function later at age 70, the researchers said in JAMA Network Open. A higher waist-to-hip ratio was tied to higher mean and total diffusivity of white matter. Associations between midlife waist-to-hip ratio, working memory, and executive function were partially mediated by white matter diffusivity (P<0.05).
Across the 11 years of the study, individual improvements in dietary behavior were tied to better white matter integrity in brain regions implicated as markers for damage in aging and dementia (P<0.05). Diet improvement also was associated with better lexical fluency before false discovery rate adjustment.
The findings suggest that interventions to improve diet and manage central obesity might be best targeted in midlife to obtain good outcomes for brain and cognitive health in older age, Jensen and colleagues noted.
Growing evidence suggests that a substantial percentage of dementia may be prevented by managing modifiable risk factors in middle age, observed Sharmili Edwin Thanarajah, MD, of Goethe University Frankfurt in Germany.
"Despite the epidemiological evidence linking midlife metabolic health to dementia in later life, systematic investigation of the underlying biological mechanisms remains sparse given the long interval between adverse health behavior and onset of cognitive impairments," Edwin Thanarajah wrote in an accompanying editorial.
The Whitehall II findings "have important implications for prevention strategies: improving metabolic health and dietary quality during midlife is critical for brain health and cognition in later life," she continued. "This message is alarming in light of the obesity pandemic."
Given that diet quality improvement, rather than reduction in waist-to-hip ratio, was tied to improvements in white matter integrity in later life and "recent evidence that even brief exposure to an unbalanced diet rich in fat and sugar can directly alter brain function in healthy participants, it is crucial to integrate dietary guidelines into public health policies," Edwin Thanarajah stressed.
"Such an integration should be an independent and essential strategy for protecting brain health, alongside the evaluation of metabolic and cardiovascular risk factors," she added.
Jensen and colleagues studied participants in the Whitehall II cohort, an ongoing prospective study of people who worked in British civil service. Previous research from Whitehall II linked short sleep durations with future multimorbidity and age at type 2 diabetes onset with dementia.
The current analysis included 512 participants in the diet quality cohort and 664 people in the waist-to-hip ratio cohort. In both groups, the mean baseline age was 48 and about 80% were men.
The researchers used the Alternative Healthy Eating Index (AHEI)-2010 score to measure diet quality, which was evaluated three times across 11 years based on food frequency questionnaires. The AHEI-2010 is designed to assess food choices to help reduce chronic disease risk. It is based on 11 components including fruits, vegetables, whole grains, and nuts, each scored from 0 to 10. Total score AHEI-2010 score can range from 0 (nonadherence) to 110 (perfect adherence).
Waist-to-hip ratio was measured five times over 21 years. Brain imaging and cognitive tests were performed at a mean age of 70.
White matter structural connectivity was assessed with diffusion tensor imaging. Hippocampal functional connectivity was evaluated by functional MRI. Cognitive tests examined working memory, semantic and lexical fluency, and executive function.
At baseline, the mean AHEI-2010 score at baseline was 55.6, indicating a generally unhealthy diet. Mean diet quality remained consistent during the 11-year follow-up, and the mean AHEI-2010 score did not meet the cutoff for a healthy diet at any wave of the study.
Waist-to-hip ratio increased nonlinearly over the 21-year measurement period. A higher midlife waist-to-hip ratio was associated with lower cognitive performance on verbal episodic memory, digit span digit coding, and trail-making tests (all P<0.05).
The study had several limitations, Jensen and colleagues acknowledged. Dietary information was collected by self-reported food frequency questionnaires and may have errors. The study cohort was predominantly white British males with high educational levels, and was generally healthier than the U.K. population.
Disclosures
This work was supported by grants from the NIHR Oxford Health Biomedical Research Centre and the Wellcome Centre for Integrative Neuroimaging.
Jensen reported receiving grants from the Wills Trust, the Wellcome Trust/NIHR, the Oxford Biomedical Research Centre, and the HDH Wills 1965 Charitable Trust during the conduct of the study.
Co-authors reported relationships with nonprofit groups.
Edwin Thanarajah reported receiving support from the Leistungszentrum Innovative Therapeutics, funded by the Fraunhofer Society and the Hessian Ministry of Science and Art; the Bundesministerium für Bildung und Forschung INITIALISE Advanced Clinician Scientist Program; and the REISS Foundation.
Primary Source
JAMA Network Open
Source Reference: Jensen DEA, et al "Association of diet and waist-to-hip ratio with brain connectivity and memory in aging" JAMA Netw Open 2025; DOI: 10.1001/jamanetworkopen.2025.0171.
Secondary Source
JAMA Network Open
Source Reference: Edwin Thanarajah S "Midlife dietary quality and body composition relevance for brain connectivity and cognitive performance in later life" JAMA Netw Open 2025; DOI: 10.1001/jamanetworkopen.2025.0181.
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