How is your competent? doctor ensuring that you don't get muscle loss/sarcopenia? DOING NOTHING? So, you DON'T have a functioning doctor, do you?
Sarcopenia has been known as a problem for a long time. And your incompetent doctor has done nothing in the past 9+ years I bet!
Creatinine-Cystatin C Ratio May Be a Predictive Biomarker for Sarcopenia in Midlife Women
Having a low creatinine-cystatin C ratio (CCR) at baseline was associated with lower fat-free muscle volumes and poorer gait speeds 6.6 years later in midlife women, according to a study published in the journal Menopause.
“The potential of CCR as a predictive biomarker for adverse events related to sarcopenia in midlife women merits further investigation,” wrote Eu-Leong Yong, National University of Singapore, Singapore, and colleagues.
To date, muscle mass is most accurately measured with 3D-imaging technologies, such as MRI. However, these tests are expensive and rely on highly trained staff to compute highly technical calculations. Other types of available diagnostics, such as measures of handgrip strength and physical performance, are time-consuming and require specially trained personnel. There is a need for simpler and more practical methods that can simultaneously assess total skeletal muscle mass and function.
For the current study, the researcher examined 891 participants (baseline mean age, 56.2 ± 6.0 years) from the Integrated Women's Health Programme (IWHP) cohort who attended both baseline and follow-up visits, and underwent objectively measured muscle strength and physical performance assessments and MRI. Creatinine to cystatin C ratio was calculated as (creatinine [mg/dL] / cystatin C [mg/L]) and low CCR were those in the lowest tertile (CCR <8.16).
Baseline low CCR was associated with lower MRI-measured muscle volumes and poorer physical function 6.6 years later.
Compared with the high CCR group, mean fat-free thigh muscle volume of the low CCR group was 0.350 L lower after adjustment for covariates. Similarly, the low CCR group was associated with 0.029 m/s slower mean usual gait and 0.049 m/s slower mean narrow gait speeds.
CCR was not associated with handgrip strength and repeated chair stands and one-leg stand tests.
“Because both muscle volume and poorer gait speed are constituents of current diagnostic criteria of sarcopenia, CCR may be a tool to help identify midlife women at risk of developing early sarcopenia and associated probability of adverse health outcomes,” commented Stephanie Faubion, MD, Mayo Clinic, Rochester, Minnesota, and the Medical Director of The Menopause Society. “Regardless of baseline risk, all midlife women should strive to mitigate loss of muscle mass with regular resistance training and adequate dietary protein intake to help prevent frailty as they age.”
SOURCE: The Menopause Society
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