Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, March 30, 2025

Mitochondrial and peroxisomal fission in cortical neurogenesis

 Ask your competent? doctor if this is enough to UNDERSTAND EXACTLY HOW TO MAKE NEUROGENESIS REPEATABLE ON DEMAND! And then CREATE PROTOCOLS TO DO THAT!

Your competent? stroke medical 'professionals' have been working on mitochondrial fission for over a decade, right? Oh NO!  You just realized the whole stroke medical world is FUCKING INCOMPETENT! Your solution is to not have a stroke! 

Mitochondrial and peroxisomal fission in cortical neurogenesis

https://doi.org/10.1016/j.biocel.2025.106774
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Abstract

The human brain is unique in its cellular diversity, intricate cytoarchitecture, function,and complex metabolic and bioenergetic demands, for which mitochondria and.peroxisomes are essential. Beyond providing energy in the form of ATP, mitochondria.and peroxisomes are multifunctional organelles that coordinate various signaling.pathways central to neurogenesis. The dynamic morphological changes of the.mitochondrial network have been linked to the regulation of bioenergetic and metabolic.states. Specific protein machineries are dedicated to mitochondrial fission and fusion,which allow for organelle distribution during cell division, organelle repair, and.adaptation to environmental stimuli (excellent reviews have been published on these.topics [Kondadi & Reichert 2024; Giacomello et al. 2020; Tilokani et al. 2018; Kraus et.al. 2021; Navaratnarajah et al. 2021]). This review focuses primarily on the machinery.involved in mitochondrial and peroxisomal fission. Mitochondrial fission enables cells to.detect and respond to external signals, making it a critical determinant of cell fate.decisions (Iwata et al. 2023; Iwata et al. 2020; Khacho et al. 2016; King et al. 2021;Prigione & Adjaye 2010; Vantaggiato et al. 2019; Rosenberg et al. 2023, Kleele et al.2021, Kraus et al., 2021). The connection between alterations in peroxisomal fission.and metabolic changes associated with cellular differentiation remains less clear. Here,we provide an overview of the functional and regulatory aspects of the mitochondrial.and peroxisomal fission machineries and provide insight into the current mechanistic.understanding by which mitochondrial and peroxisomal fission influence neurogenesis.

Introduction

The human brain is unique in its cellular diversity, intricate cytoarchitecture, function, and complex metabolic and bioenergetic demands, for which mitochondria and peroxisomes are essential. Mitochondria are multifunctional organelles that coordinate various signaling pathways central to neurogenesis. The dynamic morphological changes of the mitochondrial network have been linked to the regulation of bioenergetic and metabolic states. Specific protein machinery is dedicated to mitochondrial fission and fusion, allowing organelle distribution during cell division, organelle repair, and adaptation to environmental stimuli (excellent reviews have been published on these topics [Kondadi & Reichert 2024; Giacomello et al. 2020; Tilokani et al. 2018; Kraus et al. 2021; Navaratnarajah et al. 2021]). In parallel, peroxisomes contain over 50 different enzymes which regulate metabolic functions that are critical for neurogenesis (Berger et al., 2016, Hulshagen et al., 2008). Peroxisomes share many of the components of their fission machinery with the mitochondria and undergo fission to help meet metabolic demands in response to environmental stimuli (Schrader et al. 2016). This review focuses primarily on the machinery involved in mitochondrial and peroxisomal fission. Mitochondrial fission has been identified as a critical determinant of cell fate decisions (Iwata et al., 2023, Iwata et al., 2020, Khacho et al., 2016, King et al., 2021, Prigione and Adjaye, 2010, Vantaggiato et al., 2019, Kraus et al., 2021). The connection between alterations in peroxisomal fission and metabolic changes associated with cellular differentiation remains less clear. Here, we provide an overview of the functional and regulatory aspects of the mitochondrial and peroxisomal fission machinery and provide insight into the current mechanistic understanding by which mitochondrial and peroxisomal fission influence neurogenesis.

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