Deans' stroke musings: Physical activity and risk of Alzheimer disease: A 2-sample Mendelian randomization study

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, October 22, 2020

Physical activity and risk of Alzheimer disease: A 2-sample Mendelian randomization study

Not understandable to me, maybe you'd rather try this article?

This one suggests 8900 steps a day.

Can Exercise Protect Against Alzheimer's?

The latest here:

Physical activity and risk of Alzheimer disease: A 2-sample Mendelian randomization study

Baumeister SE, Karch A, Bahls M, et al.

Neurology|September 29, 2020

Researchers assessed if physical activity can protect against Alzheimer disease (AD) via a 2-sample Mendelian randomization analysis. They used summary data on genome-wide association studies regarding physical activity and AD. The sample consisted of 21,982 patients with AD and 41,944 controls who were cognitively normal. Eight single nucleotide polymorphisms (SNPs) known at p < 5 × 10⁻⁸ to be linked to average accelerations and 8 SNPs correlated at p < 5 × 10⁻⁷ linked with vigorous(definition?) physical activity (fraction of accelerations > 425 milligravities) acted as instrumental variables. Genetic liability for fraction of accelerations >425 milligravities was irrelevant to the risk of AD. A causal link between physical activity and AD risk is not confirmed by the current research.

Read the full article on Neurology.