Deans' stroke musings: Is periodontitis a risk factor for ischaemic stroke, coronary artery disease and subclinical atherosclerosis? A Mendelian randomisation study

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, October 22, 2020

Is periodontitis a risk factor for ischaemic stroke, coronary artery disease and subclinical atherosclerosis? A Mendelian randomisation study

Periodontitis (per-e-o-don-TIE-tis), also called gum disease, is a serious gum infection that damages the soft tissue and, without treatment, can destroy the bone that supports your teeth. Periodontitis can cause teeth to loosen or lead to tooth loss.

Maybe you want to take care of your gum disease for this reason?

Are your gums saying something about your dementia risk?

The latest here:

Is periodontitis a risk factor for ischaemic stroke, coronary artery disease and subclinical atherosclerosis? A Mendelian randomisation study

Bell S, Gibson JT, Harshfield EL, et al.

Atherosclerosis|October 5, 2020

Given that periodontitis and cardiovascular disease are linked in observational studies, researchers assessed if periodontitis is causally related to stroke, coronary artery disease, or subclinical atherosclerosis via Mendelian randomization. A two-sample Mendelian randomization analysis was performed using five single nucleotide polymorphisms previously linked with periodontitis in genome-wide association studies. Summary data have been collected from MEGASTROKE and combined with de novo analyses of UK Biobank for stroke and its major subtypes (up to 44,221 cases, 739,957 controls) and CARDIoGRAMplusC4D and UK Biobank for coronary artery disease (122,733 cases, 424,528 controls). According to results, there was no connection between periodontitis and any stroke, ischemic stroke or any major subtypes, or coronary artery disease. Similarly, no link was identified between periodontitis and subclinical atherosclerosis. This indicates that associations identified in observational studies may represent confounding.

Read the full article on Atherosclerosis.