Deans' stroke musings: “Morning People” at Higher Risk of Alzheimer Disease

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Thursday, October 29, 2020

“Morning People” at Higher Risk of Alzheimer Disease

This is most certainly not me.

“Morning People” at Higher Risk of Alzheimer Disease

A higher risk of Alzheimer disease was associated with early risers, a new study published in Neurology reports. The study found no link between major depressive disorder and Alzheimer disease.

Although previous studies report comorbidity of depressive disorders and neurodegenerative diseases such as Alzheimer disease, the researchers wanted to find out if a causal relationship exists between them as well as between Alzheimer disease and other abnormal sleep patterns.

The researchers conducted a bidirectional two-sample Mendelian randomization (MR) study. A genome-wide association study used data from the UK Biobank, the Psychiatric Genomics Consortium database, and the International Genomics of Alzheimer’s Project.

The authors found no causal relationship between major depression and sleep-related phenotypes, nor did they find statistically significant relationships between major depression and Alzheimer disease.

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“Morning people” had genetically higher risks of Alzheimer disease, a lower risk of insomnia, and shorter sleep duration. They were also less likely to report long sleep. They also found people with higher risk of Alzheimer disease generally have a lower risk of insomnia.

Limitations include the fact that MR may overestimate the effect of clinical intervention on outcomes. In addition, the researchers obtained data only from middle-age or older individuals.

“Future work could explore the genetic heterogeneity of depression syndromes to test for causal relationships between potentially aetiologically distinct sub-types of depression (eg, late-onset depression) and Alzheimer’s disease,” the researchers concluded.

Reference

Huang J, Zuber V, Matthews PM, Elliott P, Tzoulaki J, Dehghan A. Sleep, major depressive disorder, and Alzheimer disease: A Mendelian randomization study. Neurology. 2020 Oct 6;95(14):e1963-e1970. doi: 10.1212/WNL.0000000000010463

This article originally appeared on Psychiatry Advisor