Deans' stroke musings: Circulating lipoprotein lipids, apolipoproteins and ischemic stroke

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, October 17, 2020

Circulating lipoprotein lipids, apolipoproteins and ischemic stroke

No clue.

Circulating lipoprotein lipids, apolipoproteins and ischemic stroke

Yuan S, Tang B, Zheng J, et al.

Annals of Neurology |October 12, 2020

Researchers assessed the comparative effects of lipids and apolipoproteins on ischemic stroke in this Mendelian randomization (MR) study. Instrumental variables were single‐nucleotide polymorphisms correlated with low‐ and high‐density lipoprotein (LDL and HDL) cholesterol, triglycerides, and apolipoprotein A‐I and B (apoA‐I and apoB) at the level of genomewide significance in the UK Biobank. In the main and sensitivity univariable MR analyses, an association of increased levels of apoB, LDL cholesterol, and triglycerides with a higher risk of any ischemic stroke, large artery stroke, and small vessel stroke was seen. This MR study shows that apoB is the predominant trait that accounts for the etiological basis of apoB, LDL cholesterol, and triglycerides in relation to ischemic stroke, especially large artery and small vessel stroke. Whether HDL cholesterol has a protective effect on ischemic stroke independent of apoA‐I requires further study.

Read the full article on Annals of Neurology .