Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, July 31, 2021

Driving Patterns Pinpoint Early Alzheimer's Disease

 This is obviously special GPS since normal GPS accuracy is 5-10 meters I don't see how this prediction is possible. You'd have to drive off the road before normal GPS recognizes it.

With your good chance of getting dementia this test should be prescribed by your doctor to establish a baseline for you. And then if found implement THOSE EXACT DEMENTIA PREVENTION PROTOCOLS  your doctor should have competently already set up.

Your risk of dementia, has your doctor told you of this?

1. A documented 33% dementia chance post-stroke from an Australian study?   May 2012.

2. Then this study came out and seems to have a range from 17-66%. December 2013.`    

3. A 20% chance in this research.   July 2013.

4. Dementia Risk Doubled in Patients Following Stroke September 2018 

The latest here:

 

Driving Patterns Pinpoint Early Alzheimer's Disease

Subtle shifts in on-road behavior suggest GPS-based biomarkers may have merit

Driving behavior captured with a global positioning system (GPS) device discerned whether cognitively normal older drivers had preclinical Alzheimer's disease, an early stage when Alzheimer's pathology has developed but cognitive changes aren't apparent.

Models to identify preclinical Alzheimer's with GPS data had an F1 score of 82% using driving indicators alone; 88% using age and driving; and 91% using age, APOE4 genotype, and driving, reported Sayeh Bayat, a PhD candidate in biomedical engineering at the University of Toronto, who presented the findings at the 2021 Alzheimer's Association International Conference, held virtually and in Denver.

The model that included age, APOE4 genotype, and driving indicators had an area under the receiver operating curve of 0.96. APOE4 status and age were the two most important features for predicting preclinical Alzheimer's disease. The most important driving feature was vehicle jerk, a measure of driving smoothness.

"We found that using machine learning methods, we can identify very subtle patterns in driving that are associated with preclinical Alzheimer's disease," Bayat told MedPage Today. "When developed to its full potential, a GPS driving biomarker can be a more affordable and scalable alternative to available procedures and methods."

"As opposed to providing an assessment of the patient's status at a given point in time, this biomarker can provide means for continuous monitoring of complex everyday activities and can help identify the behavioral changes that are related to the earliest underlying neurobiological changes," she added.

"Moving toward using readily available and accessible embedded technologies to monitor brain-related behaviors is where the future is headed," observed Rhoda Au, PhD, of Boston University, who wasn't involved with the study.

"Given that everything we do, we do through our brains, by monitoring our everyday actions we are essentially getting a continuous window into our brain function," Au told MedPage Today.

"We can use this information to detect the earliest signs of Alzheimer's disease, potentially intervene when interventions would be most effective, and alter the trajectory of decline to such an extent that we may be able to prevent Alzheimer's altogether," she continued. "This study shows that this imagined future is soon upon us."

In their study, Bayat and co-authors tracked cognitively normal older drivers for 1 year, from January 1 to December 31, 2019, with an in-vehicle GPS data logger. The data logger and custom software were part of the Driving Real-World In-Vehicle Evaluation System (DRIVES), which recorded date, time, latitude and longitude coordinates, and speed every 30 seconds.

The sample included 64 people with and 75 people without preclinical Alzheimer's, assessed by cerebrospinal fluid biomarkers of amyloid-beta (Aβ42/Aβ40 ratio). Participants were enrolled in longitudinal studies on aging and dementia at the Washington University Knight Alzheimer Disease Research Center in St. Louis and drove at least weekly on average.

The researchers assessed indicators of driving performance -- speed, acceleration, and vehicle jerk characteristics, as well as aggressive driving incidents, such as hard braking -- and indicators of driving space, like number of night trips and unique destinations.

People with preclinical Alzheimer's were 79 years old on average; those without preclinical signs were 77. In both groups, about one-third of participants were APOE4 carriers and about half were women. Most participants were white.

The five most important driving features included two items that described driving performance (average jerk and over-speeding) and three that involved driving space (total number of night trips, radius of gyration, and number of trips shorter than 1 mile).

The study had several limitations. There was no automatic method to identify drivers and ensure friends or family members weren't driving, though the study took steps to control for that, Bayat said.

All participants were from the St. Louis area and the findings might not apply to others, the researchers noted, adding that in the future, larger studies could evaluate how race, sex, income, education, or social and cultural norms influence driving patterns in older adults.

  • Judy George covers neurology and neuroscience news for MedPage Today, writing about brain aging, Alzheimer’s, dementia, MS, rare diseases, epilepsy, autism, headache, stroke, Parkinson’s, ALS, concussion, CTE, sleep, pain, and more. Follow

Disclosures

Participants in this study were enrolled in a longitudinal study funded by the National Institutes of Health/National Institute on Aging.

Bayat reported no conflicts of interest.

Primary Source

Alzheimer's Association International Conference

Source Reference: Bayat S, et al "Identifying preclinical Alzheimer disease from driving patterns: a machine learning approach" AAIC 2021.

 

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