Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Sunday, July 18, 2021

Dose Escalation and Safety of Capsaicin for Cerebral Perfusion Augmentation

 I think this means you're getting higher blood velocity in your brain. Sounds like a winner to get more oxygen to your brain and maybe save a few neurons from dying. But since this was tested in healthy volunteers your doctor and hospital have the responsibility to initiate research in this on stroke subjects with the objective being to see how many neurons can be saved. 

No initiation of research you need to fire the board of directors, they are not setting correct goals for the hospital and staff.  But since this is not yet proven useful for stroke survivors don't start bringing in ghost peppers(Scoville of 855,000 to 1,041,427). I don't know how to translate Scoville units to μMol(A micromole is a unit of measure defined as 10-6 (one-millionth) of a mole. The symbol for micromole is commonly umol or μmol.)

Dose Escalation and Safety of Capsaicin for Cerebral Perfusion Augmentation

 
Originally publishedhttps://doi.org/10.1161/STROKEAHA.120.032773Stroke. 2021;52:2203–2209

Background and Purpose:

Sphenopalatine ganglion (SPG) electrical stimulation has been studied in the setting of acute ischemic stroke to enhance collateral flow. Capsaicin poses an alternative to chemically stimulate the sphenopalatine ganglion. Therefore, the objective of this study was to determine the safety and effect of increasing doses of capsaicin upon serial transcranial Doppler markers of cerebral blood flow.

Methods:

We performed serial transcranial Doppler testing in 30 healthy volunteers divided into 5 equal groups. Capsaicin doses ranged from 33 to 165 μMol. We recorded peak systolic and end-diastolic velocities in the middle cerebral artery, arterial pressure, and perceived pungency in 5-minute intervals up to 20 minutes. We then calculated the mean velocity, the pulsatility index, and the cerebral blood flow index.

Results:

The participants’ median age was 21 years (range, 5 years); all reported consumption of capsaicin in their diets. After and during the study, none reported side effects. Perceived pungency peaked at 5 minutes, and by the 20-minute mark, none perceived any pungency. All the tested doses produced the same pattern, consisting of augmentation of the middle cerebral artery mean velocity with the pulsatility index’s diminution. The effects peaked between the 5- and the 10-minute measurements and then returned to basal levels except for the 66-μMol doses, which produced a sustained effect. We found no correlation between perceived pungency and dose, but the middle cerebral artery mean velocity was strongly correlated with the dose administered.

Conclusions:

This study provides evidence supporting the safety and tolerability of oral capsaicin in a population of healthy volunteers. Capsaicin appears to produce effects similar to those of sphenopalatine ganglion electrical stimulation.

Registration:

URL: https://www.clinicaltrials.gov; Unique identifier: NCT04545892.

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