Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Saturday, July 31, 2021

Emerging Roles of Oxidative Stress in Brain Aging and Alzheimer's Disease

 They talk of antioxidants, caloric restriction and physical activity reducing oxidative stress but give no clues that they have written EXACT REHAB PROTOCOLS to prevent this problem. So if no protocols were written it is useless.

Emerging Roles of Oxidative Stress in Brain Aging and Alzheimer's Disease

 

Carl W.Cotmana
Under a Creative Commons license
open access

Highlights

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Oxidative stress is involved in the progression of aging and Alzheimer's disease (AD)

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Free radicals damage mitochondria, increasing production of toxic amyloid beta (Aβ)

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DNA repair dysfunction is more severe in the AD brain than in the aged brain

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Inhibiting oxidation-induced epigenetic changes can improve cognition and reduce Aβ

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Long term exercise effectively reduces oxidative stress and improves cognition

Abstract

Reactive oxygen species (ROS) are metabolic byproducts that are necessary for physiological function but can be toxic at high levels. Levels of these oxidative stressors increase gradually throughout the lifespan, impairing mitochondrial function and damaging all parts of the body, particularly the central nervous system. Emerging evidence suggests that accumulated oxidative stress may be one of the key mechanisms causing cognitive aging and neurodegenerative diseases such as Alzheimer's disease (AD). Here, we synthesize the current literature on the effect of neuronal oxidative stress on mitochondrial dysfunction, DNA damage and epigenetic changes related to cognitive aging and AD. We further describe how oxidative stress therapeutics such as antioxidants, caloric restriction and physical activity can reduce oxidation and prevent cognitive decline in brain aging and AD. Of the currently available therapeutics, we propose that long term physical activity is the most promising avenue for improving cognitive health by reducing ROS while promoting the low levels required for optimal function.

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