Candesartan Mitigates Paclitaxel-Induced Peripheral Neuropathy in Human Neuron Cells: A Comprehensive in Vitro Evaluation

 

But shouldn't your doctor already be using Candesartan on you? Or are they that incompetent that they don't follow and implement research?

Bacause of this piece of the neuronal cascade of death!

glutamate poisoning

 

generic drug candesartan (brand name: ATACAND®) Blood Pressure Drug Helps Alzheimer's June 2018

 This line from there is instructive:

The scientists found that candesartan prevented glutamate-induced neuronal death.

Candesartan Mitigates Paclitaxel-Induced Peripheral Neuropathy in Human Neuron Cells: A Comprehensive in Vitro Evaluation

•          Karar H. Alfarttoosi Department of Pharmacology, College of Pharmacy, Ahl Al-Bayt University, Karbala, Iraq.
• Ihsan S. Rabeea Department of Clinical Pharmacy and Therapeutics, College of Pharmacy, Kufa University, Najaf, Iraq

DOI:

https://doi.org/10.31351/vol33iss(4SI)pp67-76

Abstract

Paclitaxel (Taxol) belongs to the initial taxane category and is employed for treating diverse types of cancers, including ovarian, lung, and breast cancers. Paclitaxel is associated with the highest prevalence of peripheral neuropathy. The detection of PIPN may necessitate a reduction in dosage or discontinuation of treatment, which can have consequences for cancer care. Activation of AT2R has shown neuroprotective effects in different rodent models. this study aims to assess the potential impact of candesartan in mitigating the deleterious effect on human neuron cells. The methods involved in Immunocytochemistry to characterize the neuron cells depend on the expression of the B tubulin III protein. WST-8 test was used on human neuron cell culture to assess the individual and combined cytotoxicity and inhibition ratio (IR%) of Taxol and candesartan. The Chou-Talalay index (CI) equation was utilized to determine if the interaction was antagonistic, additive, or synergistic. As well as investigating the morphological change. The results, findings demonstrated a notable increase in the inhibitory ratio (IR%) when comparing Taxol to the control group at all serial concentrations, with statistical significance (P<0.05). on the other hand, candesartan did not show any significant difference compared to the control group (P>0.05). Interestingly, the combination treatment group showed a significant reduction in the inhibitory ratio (IR%) when compared to the Taxol group. the estimated Chou-Talalay indices (CI) values suggest a significant antagonistic interaction between Taxol and candesartan at different dosages in sequential concentrations (CI>1.1).The morphology imaging of neuron cells after treatment reveals enhanced neuronal cell morphology when using combination Taxol and candesartan. In conclusion, candesartan exhibits the potential to mitigate the cytotoxicity effect of Taxol chemotherapy.         

How to Cite

Karar H. Alfarttoosi, Ihsan S. Rabeea. Candesartan Mitigates Paclitaxel-Induced Peripheral Neuropathy in Human Neuron Cells: A Comprehensive in Vitro Evaluation. Iraqi Journal of Pharmaceutical Sciences [Internet]. 2025 Feb. 15 [cited 2025 Feb. 17];33((4SI):67-76. Available from: https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/3529