Gut Microbe Secreted Molecule Linked to Formation of New Nerve Cells in Adult Brain

What do I need to eat to generate 5.5 billion neurons in my brain? Why does no one know that answer? 

Gut Microbe Secreted Molecule Linked to Formation of New Nerve Cells in Adult Brain

Summary: Gut microbes that metabolize tryptophan secrete indoles that stimulate the development of new neurons in the adult brain.

Source: Singhealth

The billions of microbes living in your gut could play a key role in supporting the formation of new nerve cells in the adult brain, with the potential to possibly prevent memory loss in old age and help to repair and renew nerve cells after injury, an international research team spanning Singapore, UK, Australia, Canada, US, and Sweden has discovered.

The international investigating team led by Principal Investigator Professor Sven Pettersson, National Neuroscience Institute of Singapore, and Visiting Professor at Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore (NTU Singapore), and Sunway University, Malaysia, found that gut microbes that metabolise tryptophan – an essential amino acid – secrete small molecules called indoles, which stimulate the development of new brain cells in adults.

Prof Pettersson and his team also demonstrated that the indole-mediated signals elicit key regulatory factors known to be important for the formation of new adult neurons in the hippocampus, an area of the brain also associated with memory and learning. Memory loss is a common sign of accelerated ageing and often an early sign of the Alzheimer’s disease (AD).

drugs to mimic the action of indoles to stimulate the production of new neurons in the hippocampus or to replace neurons damaged by stroke and spinal injury, as well as designing dietary intervention using food products enriched with indoles as a preventive measure to slow down aging,” said Prof Pettersson.

The international study involved researchers from multiple disciplines and institutions around the world including:

• UK Dementia Research Institute at Imperial College London, UK
• Karolinska Institute, Sweden
• NTU Lee Kong Chian School of Medicine, Singapore
• Murdoch University, Australia
• National Neuroscience Institute, Singapore
• Pennsylvania State University, USA
• University of Toronto, Canada
• Sunway University Malaysia

“The work reported in this paper addresses the formation of neurons in the adult brain. We are currently assessing whether indoles can also stimulate early formation of neurons during brain development. Another area of potential intervention interest is in situations of stroke or spinal injury where there is an urgent need to generate new neurons. It is an interesting and exciting time ahead of us,” said Prof Pettersson.