Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, October 25, 2022

Advancement of epigenetics in stroke

If there is something in here you'll have to ask your doctor what the full research says.

Advancement of epigenetics in stroke

  • 1Department of Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China
  • 2Laboratory of Neurological Diseases and Brain Function, The Affiliated Hospital of Southwest Medical University, Luzhou, China
  • 3Institute of Epigenetics and Brain Science, Southwest Medical University, Luzhou, China
  • 4Academician (Expert) Workstation of Sichuan Province, The Affiliated Hospital of Southwest Medical University, Luzhou, China
  • 5Sichuan Clinical Research Center for Neurosurgery, The Affiliated Hospital of Southwest Medical University, Luzhou, China

A wide plethora of intervention procedures, tissue plasminogen activators, mechanical thrombectomy, and several neuroprotective drugs were reported in stroke research over the last decennium. However, against this vivid background of newly emerging pieces of evidence, there is little to no advancement in the overall functional outcomes. With the advancement of epigenetic tools and technologies associated with intervention medicine, stroke research has entered a new fertile. The stroke involves an overabundance of inflammatory responses arising in part due to the body’s immune response to brain injury. Neuroinflammation contributes to significant neuronal cell death and the development of functional impairment and even death in stroke patients. Recent studies have demonstrated that epigenetics plays a key role in post-stroke conditions, leading to inflammatory responses and alteration of the microenvironment within the injured tissue. In this review, we summarize the progress of epigenetics which provides an overview of recent advancements on the emerging key role of secondary brain injury in stroke. We also discuss potential epigenetic therapies related to clinical practice.

Introduction

Stroke is one of the main leading causes of death and the first leading cause of disability worldwide (Avan et al., 2019; Collaborators, 2019). Hemorrhagic stroke, including intracerebral hemorrhage (ICH) and subarachnoid hemorrhage (SAH), happens when a blood vessel in the brain bursts or when brain tissue starts to bleed. On the other hand, ischemic stroke (IS) directly results from the disruption of blood supply to the brain and constitutes approximately 85% of all known cases of stroke. After the stroke, injured brain parenchyma initiates biochemical cascades, which include energy failure, ionic pump failure, oxidative damage, cell death, and inflammation, eventually leading to irreversible brain damage (Iglesias-Rey et al., 2022). Additionally, patients surviving stroke may suffer from functional disabilities that might require temporary or lifelong assistance (Aslanyan et al., 2003). Thus, understanding stroke at the molecular level will help researchers to produce key therapeutic strategies to minimize secondary injuries and promotion of neuroprotection associated with stroke (Saini et al., 2021).

Over the past few decades, researchers have advanced in our understanding of the epigenetic mechanisms involved in the central nervous system (CNS) and its role in neuropsychiatric disorders (Szyf, 2015). These epigenetic-related findings also offer the important translational potential for stroke research. Thus, fully understanding the role of epigenetic regulators in the stroke process is crucial to harness the potential of epigenetic therapies. Here, we review three epigenetic mechanisms involved in secondary brain injuries post-stoke: histone modification, DNA-methylation, and RNA modifications. We also discuss the relevant clinical treatment targeting epigenetics and summarize future advancements in this field.

More at link.

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