Future of Brain–Gut Behavior Therapies: Mediators and Moderators

Ask your doctor if something in here from gut to brain will improve stroke recovery. There is all this earlier research your competent doctor should know about. If your doctor has done nothing with this, you don't have a functioning stroke doctor. Yeah, it's probably newer than medical school but I expect my doctors and therapists to be up-to-date on all things stroke. If I wanted to stay employed as a programmer I had to learn the newest all the time.

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Future of Brain–Gut Behavior Therapies: Mediators and Moderators

Author links open overlay panelHelenBurton MurrayPhD^abc

BrjánnLjótssonPhD^d

https://doi.org/10.1016/j.gtc.2022.06.011Get rights and content

Keywords

Cognitive-behavioral therapy

Exposure therapy

Disorders of gut–brain interaction

Functional gastrointestinal disorders

Irritable bowel syndrome

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Helen Burton Murray, PhD *, Brjánn Ljótsson, PhD 

INTRODUCTION Brain–gut behavior therapies are efficacious treatments for disorders of gut–brain interaction (DGBI; also known as functional gastrointestinal [GI] disorders). 1 There is a large body of evidence supporting the efficacy of brain–gut behavior therapies for irritable bowel syndrome (IBS)2,3 and emerging evidence for other DGBI (eg, supragastric belching,4 functional dyspepsia).5,6 Often used in combination with other approaches(eg,neuromodulation),brain–gut behavior therapies increasingly Funding: This article was supported by the National Institute of Diabetes and Digestive and Division of Gastroenterology, Massachusetts General Hospital, 55 Fruit Street, Boston, MA 02114, USA; Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA; Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Department of Clinical Neuroscience, Division of Psychology, Karolinska Institutet, Nobels va ̈ g 9, Solna, Stockholm 171* Corresponding author. Massachusetts General Hospital, Division of Gastroenterology, 55 Fruit Street, Boston, MA 02114 hbmurray@mgh.harvard.edu KEYWORDS Cognitive-behavioral therapy Exposure therapy Disorders of gut–brain interaction Functional gastrointestinal disorders Irritable bowel syndrome Brain–gut behavior therapies for disorders of gut–brain interaction have included therapies with different theorized targets. There is a large knowledge gap regarding the processes through which brain–gut behavior therapies achieve change in disorders of gut–brain interaction. Consistent evidence suggests that gastrointestinal-specific cognitive, affective, and behavioral processes are the primary targets of brain–gut behavior therapies, leading to clinical improvements. Future research is needed to evaluate other target mechanisms and moderators, including understanding of which treatment techniques are most potent and why and for whom they are most beneficial.