http://pubs.rsc.org/en/content/articlelanding/2017/nr/c7nr06528k#!divAbstract
Could we do nasal route instead of injections?
Abstract
Brain injury is a
devastating medical condition and represents a major health problem. For
such disease, tissue and organ reconstruction has been regarded as a
promising therapeutic strategy. Here, we propose a regenerative
methodology focusing on the provision of functionalized nanopeptide
scaffold to facilitate angiogenesis and neurogenesis at the brain injury
site. The peptide, RADA16-SVVYGLR, undergoes self-assembling process to
construct an interconnected network with intertwining nanofibers and
can be controlled to display various physicochemical properties by the
adjustment of microenvironmental factors such as pH value and ions
concentration. Such scaffold is capable of supporting endothelial cells
to form tube-like structure and neural stem cells to survive and
proliferate. In in vivo zebrafish brain injury model, sprouting
angiogenesis and developmental neurogenesis are achieved, and functional
recovery of severed optic tectum is effectively enhanced in
RADA16-SVVYGLR hydrogel-implanted group. Meanwhile, the nanopeptide
hydrogel is non-toxic to zebrafish embryo during embryonic developmental
stage. The angiogenic self-assembling peptide hydrogel has programmable
physical properties, good biocompatibility, and regenerative ability
for functional recovery in the injured brain. We suggest that
functionalized self-assembling peptide encapsulated with neural stem
cells or used alone could be an attractive and effective therapeutic
modality for the applications in brain injury and diseases (viz.,
trauma, stroke, tumor, degenerative neurological disorder, etc).
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