The Scent of Neurogenesis: Refurbish Your Brain the Pleasurable Way

Sounds promising. But will your competent? doctor do ANYTHING AT ALL with it?

 The Scent of Neurogenesis: Refurbish Your Brain the Pleasurable Way

Sharadendu Bali*
Professor General Surgery, TMMC, TMU, Moradabad, UP, India
*Corresponding Author: Sharadendu Bali, Professor General Surgery, TMMC, TMU,
Moradabad, UP, India.
Review Article
Received: March 25, 2024
Published: April 04, 2024
© All rights are reserved by Sharadendu Bali.
1. Abstract
Neurogenesis in adult mammals is prominently observed in two specific brain regions: the subventricular zone (SVZ) and the subgranular zone (SGZ) of the hippocampal dentate gyrus. Neurons born in the SVZ migrate through the rostral migratory stream (RMS) to the olfactory bulb (OB), where they differentiate into interneurons. This migration is important for the sustenance and functional adaptation of the olfactory system, which is unique in its constant turnover of sensory receptor cells. The olfactory system, by its very design, maintains a direct link with the areas of the brain responsible for controlling various behaviors and emotional responses, making it a key component in the sensory-behavioral paradigm influencing adult neurogenesis. This discussion explores the mechanisms through which odors may influence the regeneration and migration of neuronal stem cells to the olfactory bulb (OB) and, consequently, affect neurogenesis.

Neurogenesis and progenitor cells in the adult human brain: a comparison between hippocampal and subventricular progenitor proliferation

But we next need to know which starting place  will migrate neurons to the area of need.

Neurogenesis and progenitor cells in the adult human brain: a comparison between hippocampal and subventricular progenitor proliferation

Abstract

For more than a decade we have known that the human brain harbours progenitor cells capable of becoming mature neurons in the adult human brain. Since the original landmark paper by Eriksson and colleagues in 1998 there have been many studies investigating the effect depression, epilepsy, Alzheimer's disease, Huntington's disease and Parkinson's disease have on the germinal zones in the adult human brain. Of particular interest is the demonstration that there are far fewer progenitor cells in the hippocampal subgranular zone (SGZ) compared with the subventricular zone (SVZ) in the human brain. Furthermore the quantity of progenitor cell proliferation in human neurodegenerative diseases differs from that of animal models of neurodegenerative diseases; there is minimal progenitor proliferation in the SGZ and extensive proliferation in the SVZ in the human. In this review we will present the data from a range of human and rodent studies from which we can compare the amount of proliferation of cells in the SVZ and SGZ in different neurodegenerative diseases.