Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Showing posts with label Labels: 40% fatigue. Show all posts
Showing posts with label Labels: 40% fatigue. Show all posts

Saturday, July 12, 2025

An investigation of post-stroke fatigue levels and influencing factors in young and middle-aged stroke patients: a cross-sectional study

 

YOU'RE FIRED! Post stroke fatigue has been known forever, solve the problem! YOUR INCOMPETENT? DOCTOR AND HOSPITAL NEEDS TO SOLVE THE FUCKING PROBLEM!

At least half of all stroke survivors experience fatigue Known since March 2017

Or is it 70%? Known since March 2015

Or is it 40%? Known since September 2017

The latest here: 

An investigation of post-stroke fatigue levels and influencing factors in young and middle-aged stroke patients: a cross-sectional study


Abstract

There are few reported studies on post-stroke fatigue (PSF) in young and middle-aged stroke patients, however, PSF plays a key role in the patient’s disease regression. Exploring the level of PSF and the influencing factors in young and middle-aged stroke patients is crucial for determining how to reduce the level of PSF and improve the patients’ motivation for rehabilitation treatment. Therefore, this study investigated the level of PSF in young and middle-aged stroke patients and analyzed the factors influencing PSF to provide a reference or basis for healthcare professionals to develop effective and targeted PSF intervention programs. The purpose of this study was to investigate the incidence of fatigue and its related influencing factors in young and middle-aged stroke patients. A total of 300 young and middle-aged stroke patients hospitalized in the Neurology Department of a tertiary hospital in Xi’an, China, from June 13 to December 31, 2024 were consecutively recruited by convenience sampling method. According to the Fatigue Severity scale (FSS), the patients were divided into a fatigue group (FSS ≥ 36 points, 187 cases) and a non-fatigue group (FSS < 36 points, 113 cases). The general situation questionnaire, Modified Rankin Scale (mRS), Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), Pittsburgh Sleep Quality Index (PSQI) and Stroke Specific Quality of Life Scale (SS-QOL), Chronic Disease Self-efficacy Scale (CDSES) were used to investigate and study them. A logistic regression model was established and stratified analysis was conducted to explore the factors influencing PSF in young and middle-aged patients. The incidence of PSF among 300 young and middle-aged stroke patients was 62.3%, Univariate analysis showed that Pre-Stroke Fatigue (PrSF), mRS score, SAS score, SDS score, PSQI score, SS-QOL score, CDSES score, marital status and occupation were related to PSF (P < 0.05). Multivariate regression analysis revealed that marital status (OR = 8.908, 95%CI 1.776–44.674), PrSF( OR = 2.909, 95%CI 1.555–5.443), SDS score (OR = 1.099, 95%CI 1.046–1.154) and SS-QOL score (OR = 0.985, 95%CI 0.972–0.998) were associated with the occurrence of PSF. Stratified analysis showed that in the group of patients with PrSF, Be married (OR = 0.438, 95%CI 0.046–4.203), SDS score (OR = 1.052, 95%CI 0.965–1.146), SS-QOL score (OR = 0.960, 95%CI 0.937–0.984), among which the SS-QOL score was associated with the risk of PSF (P < 0.001); In the group of patients without PrSF, SDS score (OR = 1.086, 95%CI 1.033–1.142) was associated with a high risk of PSF (P < 0.001), Be married (OR = 0.060, 95% CI 0.007–0.490) and SS-QOL score (OR = 0.984, 95% CI 0.974–0.995) were associated with a low risk of PSF (P < 0.05). The fatigue status of young and middle-aged stroke patients is more serious. Clinically, we should strengthen the protection of high-risk patients with the above risk factors, and corresponding intervention programs should be formulated in time to reduce the incidence of PSF, alleviate the fatigue symptoms of patients, and enhance their quality of life.

Trial registration: Registration number of China Clinical Trials Registration Center ChiCTR2500099037.

Sunday, June 8, 2025

Behavioral and Neural correlates of Post- STROKE Fatigue: A randomized controlled trial protocol

YOU'RE FIRED! Post stroke fatigue has been known forever, solve the problem! YOUR INCOMPETENT? DOCTOR AND HOSPITAL NEEDS TO SOLVE THE FUCKING PROBLEM!

At least half of all stroke survivors experience fatigue Known since March 2017

Or is it 70%? Known since March 2015

Or is it 40%? Known since September 2017

The latest here: 

 Behavioral and Neural correlates of Post-STROKE Fatigue: A randomized controlled trial protocol

PLOS One | https://doi.org/10.1371/journal.pone.0324591 June 6, 2025 1 / 12
OPEN ACCESS

Citation:
Liao K-C, Christian I, Stewart J,
Trudelle-Jackson E, Wang W, Shang T, et al.

(2025) Behavioral and Neural correlates of

Post-stroke fatigue: A randomized controlled

trial protocol. PLoS One 20(6): e0324591.

https://doi.org/10.1371/journal.pone.0324591

Editor:
Jennifer Tucker, PLOS: Public Library
of Science, UNITED KINGDOM OF GREAT

BRITAIN AND NORTHERN IRELAND

Received:
April 7, 2025
Accepted:
April 14, 2025
Published:
June 6, 2025
Peer Review History:
PLOS recognizes the
benefits of transparency in the peer review

process; therefore, we enable the publication

of all of the content of peer review and

author responses alongside final, published

articles. The editorial history of this article is

available here:
https://doi.org/10.1371/journal.
pone.0324591

Copyright:
© 2025 Liao et al
.
This is an open
access article distributed under the terms of

the
Creative Commons Attribution License,
which permits unrestricted use, distribution,

STUDY PROTOCOL

Behavioral and Neural correlates of Post-

STROKE Fatigue: A randomized controlled trial

protocol

Kuan-Chun Liao
1, Isabelle Christian1, Jill Stewart2, Elaine Trudelle-Jackson1,
Wanyi Wang
3, Ty Shang4, Hui-Ting Goh 1*,
1
School of Physical Therapy, Texas Woman’s University, Dallas, Texas, United States of America,
2
Physical Therapy Program, Department of Exercise Science, University of South Carolina, Columbus,
South Carolina, United States of America,
3 Center for Research Design and Analysis, Texas Woman’s
University, Houston, Texas, United States of America,
4

Abstract


Introduction

Post-stroke fatigue (PSF) is highly prevalent and lacks of effective management.

Recent evidence suggest the use of transcranial direct current stimulation (tDCS) to

reduce PSF. However, the effect was not lasting and the working mechanisms was

unclear. The purpose of this study is to determine the behavioral and neurophysiolog
-
ical effects of five daily sessions of tDCS on PSF.


Methods and analysis

This will be a double-blind randomized controlled trial targeting an enrollment of 32

participants with subacute-chronic stroke and significant fatigue (average Fatigue

Severity Scale (FSS) > 4). Participants will be equally randomized to either anodal

tDCS or sham tDCS groups. The anodal tDCS group will receive 20 minutes of 2-mA

anodal tDCS applied to the ipsilesional primary motor cortex (M1) for five consecu
-
tive days. The sham tDCS group will receive the same protocol except there will be

to randomization), immediately after the intervention, and at one-month follow-up.
The primary behavioral outcome will be the FSS and the primary neurophysiological outcome will be an input-output curve of motor cortex excitability derived using tran-
scranial magnetic stimulation. Secondary behavioral outcomes will include Fatigue

Scale for Motor and Cognitive Function, Visual Analog Scale-Fatigue, Borg Rating

of Perceived Exertion, and Paas Mental Effort Rating Scale. Secondary neurophys
-
iological outcome will be the functional connectivity of the fronto-striato-thalamic

network acquired using resting state functional Magnetic Resonance Imaging (MRI).
PLOS One | https://doi.org/10.1371/journal.pone.0324591 June 6, 2025 2 / 12
Repeated measure ANOVA or ANCOVA will be conducted for all outcomes to com
-
pare the change between groups.


Discussion

Little is known about effective treatments for PSF and the underlying mechanisms of PSF. tDCS is a promising tool to provide targeted intervention to reduce PSF. The results of this clinical trial will offer critical information for PSF management and investigation. 

Trial registration This trial was registered in February 1 2024 with ClinicalTrials.gov under the registra