http://www.ncbi.nlm.nih.gov/pubmed/27363696
Demaerschalk BM1,2.
Abstract
Despite
strong evidence that intravenous tissue plasminogen activator (tPA)
improves outcomes in acute ischemic stroke patients, its use in clinical
practice remains modest. Complex eligibility criteria have been
postulated as barriers to greater utilization. Further complicating this
has been multiple guidelines and prescribing labels that have been
published since first being approved for use in 1996. In this review,
several warning and exclusion criteria for tPA in acute ischemic stroke
are reviewed with the goal of providing readers a nuanced understanding
of historical context and available evidence to make informed decision.
KEYWORDS:
Alteplase; Food and Drug Administration; Guidelines; Ischemic stroke; Tissue plasminogen activator- PMID:
- 27363696
- DOI:
- 10.1007/s11883-016-0602-5
- [PubMed - in process]
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