Abstract
Background
To
estimate the strength of the cross‐sectional and longitudinal
association between arterial stiffness, measured by pulse‐wave velocity,
and cognitive function, distinguishing between global cognition,
executive functions, and memory and to examine the influence of
demographic, clinical, and assessment characteristics on this
relationship.
Methods and Results
Systematic review of MEDLINE (via PubMed), Scopus, and WOS
databases from their inception to March 2019, to identify
cross‐sectional and longitudinal studies on the association between
pulse‐wave velocity and cognitive domains (ie, global cognition,
executive functions, and memory) among adult population. A total of 29
cross‐sectional and 9 longitudinal studies support the negative
relationship between arterial stiffness and cognitive function,
including global cognition, executive function, and memory. Demographic,
clinical, and assessment characteristics did not substantially modify
the strength of this association.
Conclusions
Evidence
reveals a negative association between arterial stiffness, measured
using pulse‐wave velocity, and cognition, specifically executive
function, memory, and global cognition. This association seems to be
independent of demographic, clinical, and assessment characteristics.
These results accumulate evidence supporting that pulse‐wave velocity
assessment could be a useful tool to identify individuals at high risk
of cognitive decline or early stages of cognitive decline, to implement interventions aimed at slowing the progression to dementia.
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