Abstract
Objective
The
aim of this study was to identify the clinical efficacy of acupuncture
in combination with RehaCom cognitive training in poststroke patients
with cognitive dysfunction.
Methods/Design
This
study was a 2 × 2 factorial design randomized controlled trial
comparing acupuncture, computer-assisted cognitive rehabilitation, and
the usual treatment by per-protocol analysis. The trial was completed by
204 stroke patients, including 49 patients in a control group, 52
patients in an acupuncture treatment group, 51 patients in a RehaCom
training group, and 52 patients in an acupuncture combined with RehaCom
group. All of the patients accepted basic treatment and health
education. The interventions continued for 12 weeks (30 minutes per day,
5 days per week). The relative cognitive and functional outcomes were
measured at baseline and 12 weeks (at the end of intervention) using the
Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment
(MoCA), and Functional Independence Measure (FIM) scales.
Results
After
12 weeks of treatment, the functional statuses of the patients in each
of the 4 groups showed varying degrees of improvement. Multiple
comparisons of the changes in the MMSE, MoCA, and FIM scores indicated
that acupuncture combined with RehaCom cognitive training (ACR) had
enhanced therapeutic effects on the functional statuses of the stroke
patients (P < .05). In addition, ACR had similar therapeutic
effects on the functional statuses of the stroke patients according to
each of the assessment scales applied (P△change value MMSE = 0.399, P△MoCA = 0.794, P△FIM = 0.862).
The interaction effect values between acupuncture and RehaCom training
(acceptance or nonacceptance) were as follows: △MMSE: F = 6.251, P = .013; △MoCA: F = 4.991, P = .027; and △FIM: F = 6.317, P = .013. Further, the main effect values for acupuncture and RehaCom training were both significant (P < .05).
Conclusions
There
is an interaction effect in the treatment of stroke patients using ACR.
The use of acupuncture in combination with RehaCom training has better
therapeutic effects on the functional statuses of poststroke patients
than the use of either treatment alone, demonstrating the clinical
significance of this combination therapy.
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