Deans' stroke musings: Phase contrast-derived cerebral blood flow is associated with neurodegeneration and cerebrovascular injury in older adults

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Friday, June 13, 2025

Phase contrast-derived cerebral blood flow is associated with neurodegeneration and cerebrovascular injury in older adults

You described something, but COMPLETLY FUCKING FAILED AT ANY COHERENT EXPLANATION OF WHAT NEEDS TO BE DONE!

Phase contrast-derived cerebral blood flow is associated with neurodegeneration and cerebrovascular injury in older adults

Jeffrey D Pyne^1,2,3

Clarissa D. Morales^1,2,3

A. Zarina Kraal^1,2,3

Mohamad Alshikho^1,2,3

Patrick Lao^1,2,3

Indira Turney^1,2,3

Erica Amarante^1,2,3

Rafael V. Lippert^1,2,3

Julia F. Chang^1,2,3

Jose Gutierrez^1,2,3

Jennifer Manly^1,2,3

Richard Mayeux^1,2,3,4

Adam M. Brickman^1,2,3*

¹Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, New York, United States
²Gertrude H. Sergievsky Center, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, New York, United States
³Department of Neurology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York City, New York, United States
⁴Department of Epidemiology, Mailman School of Public Health, Columbia University, New York City, New York, United States

Global cerebral blood flow and the local delivery of blood through the vascular network are essential to maintain brain and cognitive health throughout the lifespan. In this cross-sectional study, we examined the association of overall extracranial blood flow into the brain, measured with phase contrast magnetic resonance imaging, with regional brain volumes, cortical thickness, white matter tract integrity, white matter hyperintensity volume, and cerebral microbleeds. Our study included 311 older adults (mean age: 77 years, standard deviation: 5.6) from the Washington Heights Inwood Columbia Aging Project (WHICAP), a community-based study in northern Manhattan. We found that lower extracranial cerebral blood flow is associated with lower cortical regional volumes, lower white matter tract integrity, and higher white matter hyperintensity volume. We observed that lower extracranial cerebral blood flow, quantified by total, anterior, and posterior circulations, is associated with lower white matter tract integrity in the forceps minor, cingulum cingulate gyrus, and inferior fronto-occipital fasciculus. Additionally, lower total extracranial cerebral blood flow is associated with higher white matter hyperintensity volume, a marker of small vessel cerebrovascular disease. These findings support our hypothesis that lower extracranial cerebral blood flow is associated with a greater degree of vascular injury and indicators of neurodegeneration, including in the deep white matter, and are consistent with the guiding conceptual framework that diminished extracranial blood flow could be a factor that promotes or exacerbates neurodegeneration and cerebrovascular injury in older adults. Future longitudinal studies are needed to establish causality and temporality.(What a fucking copout! You're fired!)

Keywords: cerebral blood flow, Aging, cerebrovascular, phase contrast MRI, hypoperfusion, white matter

Received: 04 Dec 2024; Accepted: 11 Jun 2025.

Copyright: © 2025 Pyne, Morales, Kraal, Alshikho, Lao, Turney, Amarante, Lippert, Chang, Gutierrez, Manly, Mayeux and Brickman. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Adam M. Brickman, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, 10032, New York, United States

Disclaimer: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.