The mentors and senior researchers failed here by not specifying that the only goal in stroke to be measured is 100% recovery! mRS = 1 is not that; NOT GOOD ENOUGH! Bad research.
Evaluation of acute mechanical revascularization in minor stroke (NIHSS score ⩽ 5) and large vessel occlusion: The MOSTE multicenter, randomized, clinical trial protocol
Abstract
Rationale:
Mechanical
thrombectomy (MT) has become the standard of care for patients with
acute ischemic stroke secondary to large vessel occlusion (LVO) of the
anterior circulation. Conversely, its benefit in patients with National
Institutes of Health Stroke Scale (NIHSS) score ⩽ 5 is unproven.
Aim:
To
demonstrate the superiority of immediate MT plus best medical treatment
(BMT) compared to BMT (with secondary MT in case of deterioration) for
increasing the rate of modified Rankin Scale (mRS) score ⩽ 1 at 90 days
after minor stroke (NIHSS score ⩽ 5) and anterior circulation LVO.
Sample size estimates:
To
detect an absolute increase of 10% (80% power) in the 90-day mRS
score = 0–1 rate in the MT + BMT group, by assuming an mRS score = 0–1
rate of 60% in the BMT group and by considering two interim
efficacy/futility analyses (after study completion by 274 and 548
patients), 824 patients must be included by 36 centers in France, Spain,
and the USA.
Methods and design:
MOSTE
is an international, multicenter, prospectively randomized into two
parallel (1:1) arms, open-label, with blinded endpoint trial.
Eligibility criteria are diagnosis of acute ischemic stroke within 23 h
of last-seen-well, NIHSS score ⩽ 5, and LVO in the anterior circulation
(intracranial internal carotid artery, M1 or M1-M2 segment of the middle
cerebral artery).
Study outcomes:
The
primary endpoint is the rate of excellent outcome at day 90 (mRS
score = 0–1). Secondary endpoints include the rates of 90-day mRS
score = 0–2 and score = 0, NIHSS score change, secondary MT,
revascularization and infarct volume growth at 24 h, and quality of life
and cognitive function at day 90. Safety outcomes (90-day all-cause
mortality, procedural complications, symptomatic intracerebral
hemorrhage, and rapid NIHSS score worsening) are recorded.
Discussion:
The MOSTE trial will determine MT efficacy and safety in patients with minor stroke and LVO in the anterior circulation.
Trial registration:
MOSTE Trial. NCT 03796468
No comments:
Post a Comment