Deans' stroke musings: Vascular recanalization exacerbates BBB permeability after ischemic stroke

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, October 6, 2025

Vascular recanalization exacerbates BBB permeability after ischemic stroke

You've known of blood brain barrier problems post stroke, WHY THE FUCK AREN'T YOU SOLVING THEM?

Inflammatory action leaking through the blood brain barrier. May 2013

A decade of complete incompetence and you're continuing that incompetence. You'll want a solution when you are the 1 in 4 per WHO that has a stroke

and by then it will be too late for them to change their recovery trajectory!

Vascular recanalization exacerbates BBB permeability after ischemic stroke

Rong-Fei Wang^1,2,3

Jing Liu³

Chang-Hui Chen²^*

¹Guangzhou University of Chinese Medicine, Guangzhou, China
²Department of Neurology, The Third Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China
³Department of Neurology, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China

Introduction: Ischemic stroke is a common and serious neurological disease. After cerebral ischemia occurs, the integrity of the BBB is disrupted, leading to increased permeability, causing pathophysiological changes such as brain edema and hemorrhagic transformation, which aggravates neuronal damage. Such changes become more obvious after the recovery of blood flow. However, the effect of vascular recanalization on blood–brain barrier leakage is poorly known.

Methods: Mice were divided into the recanalization group and the non-recanalization group. Mice in the recanalization group suffered from the middle cerebral artery occlusion and were reperfused 60 min later. Mice in the non-recanalization group suffered from permanent occlusion of the middle cerebral artery. The permeability of the blood–brain barrier was tested using fluorescence staining, and the expression of tight junction proteins and transcytosis-related proteins were analyzed by western blot.

Results: The IgG results revealed a significantly larger area of leakage in the recanalization group compared to the non-recanalization group. A consistent trend was observed in the FITC-dextran leakage experiment. Moreover, after blood flow recanalization, there was a significant reduction in tight junctions-related proteins, occludin and ZO-1. Meanwhile, both ischemia and reperfusion caused changes in the ratio of transcytosis related protein Caveolin-1 /MFSD2a, and this is more obvious in the blood flow recanalization group.

Conclusion: Vascular recanalization can exacerbate blood–brain barrier disruption, concurrently impairing both the paracellular and transcytosis pathways. This finding provides a rationale for exploring new approaches for protecting the integrity of the blood–brain barrier, reducing its permeability, and lowering the risk of hemorrhagic transformation.