Deans' stroke musings: A comparative analysis of the cholesterol–high-density lipoprotein–glucose index and the triglyceride–glucose index in predicting in-hospital mortality in critically ill ischemic stroke patients

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, October 27, 2025

A comparative analysis of the cholesterol–high-density lipoprotein–glucose index and the triglyceride–glucose index in predicting in-hospital mortality in critically ill ischemic stroke patients

Survivors actually want you to do research that prevents this problem! WITH NO LEADERSHIP IN STROKE NOTHNING EVER GETS DONE PROPERLY!

A comparative analysis of the cholesterol–high-density lipoprotein–glucose index and the triglyceride–glucose index in predicting in-hospital mortality in critically ill ischemic stroke patients

Huang Luwen

Li Linlin

Yu Ming^*^†

Xu Lei^*^†

Department of Neurology, Suining Central Hospital, Suining, Sichuan, China

Background: The Cholesterol, high-density lipoprotein, and glucose (CHG) index has emerged as a potential indicator of metabolic disturbance, but its prognostic value in patients with ischemic stroke (IS) remains unclear. This study aimed to assess whether the CHG index could predict 28-day in-hospital mortality in critically ill IS patients and to compare its performance with the established triglyceride–glucose (TyG) index.

Methods: We conducted a cohort analysis using data from the eICU database, involving 1,670 critically ill patients diagnosed with IS between 2014 and 2015. CHG and TyG indices were computed for each patient. Their associations with 28-day in-hospital mortality were examined using multivariable Cox regression. To further investigate the associations, restricted cubic spline (RCS) analysis was conducted. Kaplan–Meier curves were used to compare outcomes across different TyG and CHG groups. Predictive accuracy was compared using receiver operating characteristic (ROC) analysis. Subgroup analyses were performed to assess consistency across different clinical characteristics.

Results: Among the study population, 158 (9.46%) patients died within 28 days of hospitalization. The CHG index showed a greater association with mortality (HR 1.554; 95% CI 1.198–2.018; p < 0.001) compared to the TyG index (HR 1.436; 95% CI 1.175–1.755; p < 0.001) in unadjusted models, and both remained significant after adjustment. RCS analysis demonstrated a linear relationship between both indices and 28-day in-hospital mortality. ROC curves showed similar discriminatory ability for the CHG and TyG indices. No significant interactions were observed in subgroup analyses (p > 0.05; p for interaction >0.05).

Conclusions: Higher CHG index values are independently associated with increased 28-day mortality in critically ill IS patients, showing a linear relationship and predictive performance comparable to that of the TyG index.