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Abstract
Background and Purpose—The
identification of intrinsic factors for predicting upper extremity
motor outcome could aid the design of individualized treatment plans in
stroke rehabilitation. The aim of this study was to identify prognostic
factors, including intrinsic genetic factors, for upper extremity motor
outcome in patients with subacute stroke.
Methods—A
total of 97 patients with subacute stroke were enrolled. Upper limb
motor impairment was scored according to the upper limb of Fugl-Meyer
assessment score at 3 months after stroke. The prediction of upper
extremity motor outcome at 3 months was modeled using various factors
that could potentially influence this impairment, including patient
characteristics, baseline upper extremity motor impairment, functional
and structural integrity of the corticospinal tract, and brain-derived
neurotrophic factor genotype. Multivariate ordinal logistic regression
models were used to identify the significance of each factor.
Results—The
independent predictors of motor outcome at 3 months were baseline upper
extremity motor impairment, age, stroke type, and corticospinal tract
functional integrity in all stroke patients. However, in the group with
severe motor impairment at baseline (upper limb score of Fugl-Meyer
assessment <25), the number of Met alleles in the
brain-derived neurotrophic factor genotype was also an independent
predictor of upper extremity motor outcome 3 months after stroke.
Conclusions—Brain-derived
neurotrophic factor genotype may be a potentially useful predictor of
upper extremity motor outcome in patients with subacute stroke with
severe baseline motor involvement.
- Received August 26, 2016.
- Revision received March 24, 2017.
- Accepted April 10, 2017.
- © 2017 American Heart Association, Inc.
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