Deans' stroke musings: Psychedelic DMT decreases stroke damage, study finds

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, December 8, 2025

Psychedelic DMT decreases stroke damage, study finds

Didn't your competent? doctor start prescribing this years ago? Oh no, incompetence reigned because your doctor doesn't follow stroke research!

DMT (17 posts to November 2020)

Psychedelic DMT decreases stroke damage, study finds

DMT may protect the brain from stroke damage by stabilising the blood–brain barrier and reducing inflammation, new research suggests.

The naturally occurring psychoactive compound dimethyltryptamine (DMT) significantly reduced brain damage in animal models of stroke by protecting the blood–brain barrier – the membrane that controls what passes from the bloodstream into brain tissue – and by lowering inflammation.

DMT is a natural compound found in many plants and mammals, including humans. It is currently under clinical investigation as a neuroprotective agent to help restore brain function after stroke.Researchers in Budapest found that DMT treatment restored both the structure and function of damaged blood–brain barriers and improved astroglial cell activity – these are star-shaped support cells that assist nerve function.

Dr Marcell László is co-first author of the study.

László said: “We found that DMT significantly reduced infarct volume and oedema formation in a rat stroke model.”

Infarct volume refers to the amount of dead brain tissue, while oedema is swelling caused by excess fluid.

The researchers observed that DMT inhibited the production of inflammatory cytokines – proteins that trigger inflammation – in brain-endothelial and peripheral immune cells, and reduced the activation of brain microglia, the brain’s immune cells, through sigma-1 receptors.

Dr Judit Vigh, co-first author, said: “The therapeutic options currently available for stroke are very limited.

“The dual action of DMT, protecting the blood–brain barrier while reducing brain inflammation, offers a novel, complex approach that could complement existing treatments.”

Clinical trials assessing the safety, efficacy and long-term effects of DMT in human patients are now under way.