Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Monday, December 8, 2025

The Role of Migrasomes in Health and Disease

 

What has your doctor done with migrasomes to help stroke recovery in the 10+ years since they have been found? NOTHING LIKE USUAL?

Can this be used to direct new neurons from neurogenesis to needed areas? How come your incompetent doctor doesn't know that?

Send me personal hate mail on this: oc1dean@gmail.com. I'll print your complete statement with your name(If you can't stand by your name don't bother replying anonymously) and my response in my blog. Or are you afraid to engage with my stroke-addled mind? No excuses are allowed! You're medically trained; it should be simple to precisely state EXACTLY WHY you don't know how to use migrasomes with NO EXCUSES! Your definition of competence in stroke is obviously much lower than stroke survivors' definition of your competence! Swearing at me is allowed, I'll return the favor. Don't even attempt to use the excuse that brain research is hard.

The Role of Migrasomes in Health and Disease


PhysiologyArticles in Press
https://doi.org/10.1152/physiol.00025.2025
 

Abstract

Migrasomes are specialized organelle that form during cell migration and play a critical role in intercellular communication and disease progression. First discovered in 2012 and reported in 2015, these organelles are characterized by their unique biogenesis on retraction fibers and their role in spatiotemporal signaling, distribution of bioactive molecules, and maintenance of cellular homeostasis. This review provides a comprehensive overview of migrasome biology, exploring their discovery, mechanisms of formation, physiological functions, and pathological implications. We examine their dual roles in both health and disease, highlighting their potential as diagnostic biomarkers and therapeutic targets. Additionally, we discuss the challenges and future directions in migrasome research, emphasizing the importance of foundational discoveries and advanced methodologies to fully realize their clinical potential.
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