Deans' stroke musings: Different coffee consumption patterns affect HbA1c via propionic acid-producing gut microbiota

Changing stroke rehab and research worldwide now.Time is Brain! trillions and trillions of neurons that DIE each day because there are NO effective hyperacute therapies besides tPA(only 12% effective). I have 523 posts on hyperacute therapy, enough for researchers to spend decades proving them out. These are my personal ideas and blog on stroke rehabilitation and stroke research. Do not attempt any of these without checking with your medical provider. Unless you join me in agitating, when you need these therapies they won't be there.

What this blog is for:

My blog is not to help survivors recover, it is to have the 10 million yearly stroke survivors light fires underneath their doctors, stroke hospitals and stroke researchers to get stroke solved. 100% recovery. The stroke medical world is completely failing at that goal, they don't even have it as a goal. Shortly after getting out of the hospital and getting NO information on the process or protocols of stroke rehabilitation and recovery I started searching on the internet and found that no other survivor received useful information. This is an attempt to cover all stroke rehabilitation information that should be readily available to survivors so they can talk with informed knowledge to their medical staff. It lays out what needs to be done to get stroke survivors closer to 100% recovery. It's quite disgusting that this information is not available from every stroke association and doctors group.

Tuesday, December 16, 2025

Different coffee consumption patterns affect HbA1c via propionic acid-producing gut microbiota

Since I'm not worrying about HbA1c levels yet I don't have to figure out the definition of filtered on my 12 cup pot of coffee daily!

Different coffee consumption patterns affect HbA1c via propionic acid-producing gut microbiota

npj Science of Food , Article number: (2025) Cite this article

955 Accesses
18 Altmetric
Metrics details

We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.

Abstract

This study investigates the causal relationship between coffee consumption patterns, propionic acid-producing gut microbiota, and glycated haemoglobin (HbA1c) levels using Mendelian randomisation (MR). Genome-wide association study datasets from the UK Biobank and MiBioGen consortium were analysed, identifying a significant mediating pathway: unsweetened filter coffee consumption promotes Veillonella abundance, which in turn reduces HbA1c levels. The inverse variance weighted method served as the primary analytical approach, supported by sensitivity analyses to ensure robustness. These findings highlight the potential of unsweetened filter coffee as a dietary intervention to improve glycaemic control by modulating gut microbiota. This research provides novel insights into the coffee-intestinal microbiota-metabolism axis and offers practical guidance for diabetes management, emphasising the importance of coffee preparation methods and dietary habits in harnessing its therapeutic potential.